Seasonal changes in thermogenesis and body mass in wild Mongolian gerbils (Meriones unguiculatus)
Seasonal changes in thermogenesis and body mass in wild Mongolian gerbils (Meriones unguiculatus)
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野生蒙古沙鼠（Meriones unguiculatus）生热作用和体重的季节变化
DOI：
10.1016/j.cbpa.2007.05.012
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发表时间：
2007-10-01
影响因子：
2.3
通讯作者：
Wang, De-Hua
中科院分区：
文献类型：
--
作者：
Zhang, Zhi-Qiang;Wang, De-Hua
本研究测定了长爪沙鼠（Meriones unguiculatus）的体重（BM）、非颤抖性产热（NST）和几种生理、激素和生化指标的季节性变化。在BM、NST、棕色脂肪组织（BAT）质量和线粒体蛋白含量方面检测到性别差异。冬季（1月）和春季（5月）雄鱼的体质量和NST均高于夏季（8月），雌鱼体质量也以冬季最高，但NST全年相对稳定。冬季雄性和雌性BAT的细胞色素e氧化酶活性和线粒体解偶联蛋白1（UCP1）含量分别增加。血清瘦素浓度在冬季最低，与BM、体脂量呈正相关，与BAT、UCP1含量呈负相关。这些数据表明，野生蒙古沙鼠不依赖于减少BM，而是增加其产热能力，以科普冷应激。瘦素可能参与了长爪沙鼠能量平衡和产热的季节性调节。(c)2007年爱思唯尔公司All rights reserved.
Seasonal adjustments in body mass (BM), nonshivering thermogenesis (NST) and several physiological, hormonal, and biochemical markers were measured in wild-trapped Mongolian gerbils (Meriones unguiculatus) from Inner Mongolia, China. Sexual differences were detected in BM, NST, brown adipose tissue (BAT) mass, and mitochondrial protein content. BM and NST in males were higher in winter (January) and spring (May) than in summer (August), and BM of females was also the highest in winter, but NST remained relatively constant throughout the year. Cytochrome e oxidase activity and mitochondrial uncoupling protein 1 (UCP1) content in BAT were enhanced in winter in males or females, respectively. Serum leptin concentration was the lowest in winter and positively correlated with BM and body fat mass but was negatively correlated with BAT UCP1 content. These data suggest that wild Mongolian gerbils do not depend on a decrease in BM, but instead increase their thermogenic capacity to cope with cold stress. Leptin may be involved in the seasonal regulation in energy balance and thermogenesis in field Mongolian gerbils. (c) 2007 Elsevier Inc. All rights reserved.