Cortical sources of resting state electroencephalographic rhythms differ in relapsing-remitting and secondary progressive multiple sclerosis
Cortical sources of resting state electroencephalographic rhythms differ in relapsing-remitting and secondary progressive multiple sclerosis
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DOI：
10.1016/j.clinph.2015.05.029
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发表时间：
2016-01-01
影响因子：
4.7
通讯作者：
Lupattelli, Tommaso
中科院分区：
文献类型：
--
作者：
Babiloni, Claudio;Del Percio, Claudio;Lupattelli, Tommaso
目的：多发性硬化（MS）患者的静息状态脑电图（EEG）节律异常，但尚不清楚它们是否能反映MS亚型（表型）如复发-缓解型（RR）和继发性进行性（SP）的不同神经生理异常。记录了36名RR、23名SP和41名匹配的健康受试者的静息状态闭眼EEG活动。基于跃迁频率（TF）、个体α频率（IAF）和个体β频率（IBF）单独识别感兴趣的EEG频带。LORETA免费软件估计皮质EEG sources.Results：广泛TF-4 Hz（delta）和IAF（alpha）皮质源异常MS亚组相比，对照组。此外，TF-4 Hz源在中央，顶叶，边缘区的幅度较高，在SP相比RR subgroup.Conclusion：皮质来源的静息态脑电节律是异常的MS患者在组水平和RR和SP亚组之间的差异。未来的研究应测试这些EEG标记物在MS临床表型的诊断和管理以及治疗评价中的效用。(C)2015年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: Resting state electroencephalographic (EEG) rhythms are abnormal in multiple sclerosis (MS) patients, but it is unclear if they can reflect different neurophysiologic abnormalities in MS sub-types (phenotypes) such as relapsing-remitting (RR) and secondary progressive (SP).Methods: We tested whether cortical sources of resting state EEG rhythms are abnormal in MS patients and differ between MS phenotypes. Resting state eyes-closed EEG activity was recorded in 36 RR, 23 SP, and 41 matched healthy subjects. EEG bands of interest were individually identified based on Transition frequency (TF), Individual alpha frequency (IAF), and Individual beta frequency (IBF). LORETA freeware estimated cortical EEG sources.Results: Widespread TF -4 Hz (delta) and IAF (alpha) cortical sources were abnormal in the MS sub-groups compared to the control group. Furthermore, TF -4 Hz sources in central, parietal, and limbic regions were higher in amplitude in the SP compared to the RR sub-group.Conclusion: Cortical sources of resting state EEG rhythms are abnormal in MS patients at group level and differ between RR and SP sub-groups.Significance: Future studies should test the utility of these EEG markers in the diagnosis and management of MS clinical phenotypes and in the therapy evaluation. (C) 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.