Polysaccharides synergistic boosting drug loading for reduction pesticide dosage and improve its efficiency
Polysaccharides synergistic boosting drug loading for reduction pesticide dosage and improve its efficiency
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多糖协同提高载药量，减少农药用量，提高药效
DOI：
10.1016/j.carbpol.2022.120041
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发表时间：
2022
影响因子：
11.2
通讯作者：
Baofeng Lin
中科院分区：
文献类型：
--
作者：
Chaoran Fan;Yan Liu;Minfei Dang;Yuntong Liang;Pu Feng;Fuxiang Wei;Lihua Fu;Cuanhui Xu;Baofeng Lin
农药过度使用是可持续农业中亟待解决的问题。基于β-环糊精（β-CD）包封和海藻酸钠（Alg）交联的协同载药效应，构建了一种新的环境响应型载药系统（TMX-loaded Alg/β-CD）。通过分子模拟研究了载体结构与噻虫嗪（TMX）溶解度的关系。β-CD与TMX具有良好的结合亲和力，可使TMX溶解度增加40%。进一步与藻酸盐共负载可以使环糊精包合物的载药量加倍，高达41%。载TMX的Alg/β-CD具有良好的环境响应性控释性能，TMX缓释时间是市售制剂的7.5倍。TMX负载的Alg/β-CD对害虫的防治效果比商品TMX延长20 d，且使用后无农药残留。本研究为多糖在害虫防治和农药减量方面的商业化应用提供了一种有前景的策略。一种基于β-环糊精/海藻酸盐的高载药量、环境响应性和长效害虫防治农药载体，用于田间试验中的农药减量和增效。·多糖复合物递送系统的首次现场验证实验。·通过共负载提高农药的水溶性和负载量。·结合分子模拟研究TMX与β-CD的相互作用。·系统研究了各种环境因素对释放的影响。·在田间试验中，害虫控制比商业杀虫剂长20天。
Overuse of pesticides is an urgent issue to be solved in sustainable agriculture. Based on the synergistic drug loading effect of β-cyclodextrin (β-CD) encapsulation and alginate (Alg) cross-linking, a new environment-responsive drug delivery system (TMX-loaded Alg/β-CD) was constructed. The relationship between carrier structure and solubility of thiamethoxam (TMX) was researched by molecular simulation. β-CD has good binding affinity with TMX, which can increase TMX solubility by 40 %. Further co-loading with alginate could double the drug loading of the cyclodextrin inclusion complex up to 41 %. TMX-loaded Alg/β-CD exhibits excellent environment-responsive controlled-release performance, and TMX sustained release time is 7.5 times longer than that of commercial agents. The pest control efficacy of TMX-loaded Alg/β-CD is 20 days longer than that of commercial TMX, and the crops has no pesticide residues after using. This study provides a promising strategy for the commercial application of polysaccharide in pest control and pesticide reduction. A high drug loading, environmental response and long-term pest control pesticide carrier based on β-cyclodextrin/alginate for pesticide reduction and increase efficiency in field trials. • First field validation experiment of a polysaccharide complex delivery system. • Improving the water solubility and loading of pesticides through co-loading. • Combining molecular simulations to study the interaction of TMX with β-CD. • The effects of various environmental factors on release were systematically studied. • In field trials, pest control was 20 days longer than commercial pesticides.