Stiffness of prostate gland measured by transrectal real-time shear wave elastography for detection of prostate cancer: a feasibility study
Stiffness of prostate gland measured by transrectal real-time shear wave elastography for detection of prostate cancer: a feasibility study
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DOI：
10.1259/bjr.20180970
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发表时间：
2019-01-01
影响因子：
2.6
通讯作者：
Wan, Qinyun
中科院分区：
文献类型：
--
作者：
Ji, Yonghao;Ruan, Litao;Wan, Qinyun
目的：本研究旨在评价经直肠实时剪切波弹性成像（SWE）测量的杨氏模量对前列腺癌（PCa）的诊断价值。整个前列腺的杨氏模量定义为这些平面中结果的平均值。结果：恶性病变的弹性模量（最大弹性模量（Emax）、平均弹性模量（Emean）和最小弹性模量（Emin））均显著高于良性病变（P均< 0.05）; PCa的最佳临界值分别为128.48 kPa、62.27 kPa和20.03 kPa。敏感性分别为77.88%、81.42%和60.18%，特异性分别为85.33%、74.51%和63.73%。PSA与Emax、Emean呈正相关（r分别为0.686、0.678），与GS呈正相关（r分别为0.410、0.382）。有较高的杨氏弹性模量和恶性病变的风险较高。同时，较高的杨氏模量与较高的PSA和GS.Advances在知识：这项研究表明，SWE可以检测PCa通过量化整个前列腺的硬度是否病变已经可见或不灰度和多普勒超声。
Objective: This study aimed to evaluate the value of the Young's modulus obtained by transrectal real-time shear wave elastography (SWE) for detection of prostate cancer (PCa).Methods: 215 patients underwent SWE in six identical planes before biopsy guided with transrectal ultrasonography. The Young's modulus of the entire prostate gland was defined as the mean of the results in these planes. The measurements were compared with the pathological results, the prostate specific antigen (PSA), and the Gleason score (GS) after biopsy.Results: The Young's modulus of elasticity, including the maximum Young's modulus (Emax), the mean Young's modulus (Emean), and the minimum Young's modulus (Emin), were significantly higher in malignant lesions than those in benign lesions (all p < 0.05). The optimal cut-off values for PCa were 128.48 kPa, 62.27 kPa, and 20.03 kPa, respectively. The sensitivities were 77.88%, 81.42%, and 60.18%, respectively, and the specificities were 85.33%, 74.51 and 63.73 %, respectively. PSA positively correlated with Emax and Emean (r = 0.686 and 0.678, respectively), as did the GS (r = 0.410 and 0.382, respectively).Conclusion: The Young's modulus of entire prostate gland can be used to differentiate benign from malignant prostatic lesions. There were higher Young's modulus of elasticity and higher risk of malignant lesions. Meanwhile, higher Young's modulus correlated with higher PSA and GS.Advances In knowledge: This study indicates SWE can detect PCa by quantified the stiffness of entire prostate gland whether the lesions have been visible or not on gray-scale and Doppler ultrasound.