Lipid lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel
Lipid lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel
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DOI：
10.1093/nutrit/nux047
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发表时间：
2017-01-01
影响因子：
3.8
通讯作者：
Banach, Maciej
中科院分区：
文献类型：
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作者：
Cicero, Arrigo F. G.;Colletti, Alessandro;Banach, Maciej
近年来，人们对可能使用营养品来改善和优化血脂异常控制和治疗的兴趣越来越大。根据现有研究的数据，营养保健品可能有助于患者获得治疗性血脂目标并降低心血管残余风险。一些营养保健品具有研究证实的基本降脂特性;有些可能对非脂质心血管风险因素也有可能产生积极影响，并已被证明可以改善血管健康的早期标志物，如内皮功能和脉搏波速度。然而，支持使用单一降脂营养品或它们的组合的临床证据在很大程度上是可变的，并且对于许多营养品，证据非常有限，因此，通常是有争议的。本立场文件的目的是为尚未接受他汀类药物治疗的患者、接受他汀类药物或联合治疗但未达到血脂目标的患者以及他汀类药物不耐受的患者提供基于共识的降脂营养品最佳使用建议。本声明适用于从事血脂紊乱患者诊断和管理的医生和其他医疗保健专业人员，尤其是在初级保健环境中。
In recent years, there has been growing interest in the possible use of nutraceuticals to improve and optimize dyslipidemia control and therapy. Based on the data from available studies, nutraceuticals might help patients obtain theraputic lipid goals and reduce cardiovascular residual risk. Some nutraceuticals have essential lipid-lowering properties confirmed in studies; some might also have possible positive effects on nonlipid cardiovascular risk factors and have been shown to improve early markers of vascular health such as endothelial function and pulse wave velocity. However, the clinical evidence supporting the use of a single lipid-lowering nutraceutical or a combination of them is largely variable and, for many of the nutraceuticals, the evidence is very limited and, therefore, often debatable. The purpose of this position paper is to provide consensus-based recommendations for the optimal use of lipid-lowering nutraceuticals to manage dyslipidemia in patients who are still not on statin therapy, patients who are on statin or combination therapy but have not achieved lipid goals, and patients with statin intolerance. This statement is intended for physicians and other healthcare professionals engaged in the diagnosis and management of patients with lipid disorders, especially in the primary care setting.