A Predominantly Visual Subdivision of The Right Temporo-Parietal Junction (vTPJ)
A Predominantly Visual Subdivision of The Right Temporo-Parietal Junction (vTPJ)
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DOI：
10.1093/cercor/bhu226
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发表时间：
2016-02-01
期刊：
影响因子：
3.7
通讯作者：
Winawer, Jonathan
中科院分区：
文献类型：
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作者：
Horiguchi, Hiroshi;Wandell, Brian A.;Winawer, Jonathan
多种感觉和认知功能归因于颞顶叶交界处（TPJ）的大皮质区域。使用功能性MRI，我们报告了右侧TPJ内的一个小区域对某些简单的视觉刺激（“vTPJ”）有强烈的反应。vTPJ分布于所有右半球（n = 7），位于听觉皮层后方。为了操纵刺激和注意力，实验采用并行块设计，同时向被试提供视觉和听觉混合刺激。(1)无论被试是否注意视觉，简单的视觉刺激（平均亮度调制的光栅图案）都会引起vTPJ的鲁棒性反应；(2)与任务相关（视觉任务）时，低对比度恒定平均亮度的漂移飞靶图案会引起vTPJ的鲁棒性反应，而与任务无关（听觉任务）时，则会引起较小的反应。结果表明，在右侧TPJ中有一个聚焦的视觉反应区域，该区域受到某些视觉刺激（亮度波动）的强烈驱动，当受试者正在观看时，该区域也可能受到其他视觉刺激的驱动。这个视觉反应区域的精确定位有助于分割TPJ，并更好地了解其在视觉意识和相关疾病（如消失和忽视）中的作用。
A multiplicity of sensory and cognitive functions has been attributed to the large cortical region at the temporo-parietal junction (TPJ). Using functional MRI, we report that a small region lateralized within the right TPJ responds robustly to certain simple visual stimuli ("vTPJ"). The vTPJ was found in all right hemispheres (n = 7), posterior to the auditory cortex. To manipulate stimuli and attention, subjects were presented with a mixture of visual and auditory stimuli in a concurrent block design in 2 experiments: (1) A simple visual stimulus (a grating pattern modulating in mean luminance) elicited robust responses in the vTPJ, whether or not the subject attended to vision and(2) a drifting low-contrast dartboard pattern of constant mean luminance evoked robust responses in the vTPJ when it was task-relevant (visual task), and smaller responses when it was not (auditory task). The results suggest a focal, visually responsive region within the right TPJ that is powerfully driven by certain visual stimuli (luminance fluctuations), and that can be driven by other visual stimuli when the subject is attending. The precise localization of this visually responsive region is helpful in segmenting the TPJ and to better understand its role in visual awareness and related disorders such as extinction and neglect.