Computational Modeling of mass transfer and links to atherosclerosis
Computational Modeling of mass transfer and links to atherosclerosis
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DOI：
10.1114/1.1468890
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发表时间：
2002-04-01
影响因子：
3.8
通讯作者：
Ethier, CR
中科院分区：
文献类型：
--
作者：
Ethier, CR
在动脉粥样硬化形成的背景下，质量运输是指致动脉粥样硬化分子从流动的血液进入动脉壁的运动，反之亦然。尽管LDL转运在动脉粥样硬化斑块的形成中起着重要作用，但物质传递模式的异常本身是否是动脉粥样硬化的原因还不清楚。解决这个问题的一个强有力的方法是通过计算建模，它提供了详细的描述当地的质量传输功能。在这里，我们简要回顾了这种建模方法的策略和一些优点和缺点，然后集中在各种动脉几何形状的研究中获得的结果。总体情况是缺氧区（从血液到血管壁的低氧运输）和LDL升高区倾向于彼此共定位，并与动脉粥样硬化病变发展和/或内膜增厚区共定位。由于这些区域也倾向于具有“异常”的壁剪切应力模式，这也被认为是致动脉粥样硬化的，因此情况变得复杂。总之，这些结果表明，但不能证明，在动脉粥样硬化形成中的质量运输的作用。(C)2002生物医学工程学会。
In the context of atherogenesis, mass transport refers to the movement of atherogenic molecules from flowing blood into the artery wall, or vice versa. Although LDL transport clearly plays a role in atherosclerotic plaque development, it is much less clear whether abnormalities in mass transfer patterns are in themselves atherogenic. A powerful way of addressing this question is through computational modeling, which provides detailed descriptions of local mass transport features. Here we briefly review the strategy and some of the pros and cons of such a modeling approach, and then focus on results gained from studies in a variety of arterial geometries. The general picture is that zones of hypoxia (low oxygen transport from blood to wall) and elevated LDL tend to colocalize, with each other, and with areas of atherosclerotic lesion development and/or intimal thickening. The picture is complicated by the fact that such zones also tend to have "abnormal" wall shear stress patterns, which are also believed to be atherogenic. Taken together, these results suggest, but do not prove, a role for mass transport in atherogenesis. (C) 2002 Biomedical Engineering Society.