Biomaterials for orthopedic diagnostics and theranostics
Biomaterials for orthopedic diagnostics and theranostics
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DOI：
10.1016/j.cobme.2021.100308
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发表时间：
2021-07-10
影响因子：
3.9
通讯作者：
Benoit, Danielle S. W.
中科院分区：
文献类型：
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作者：
Ackun-Farmmer, Marian A.;Overby, Clyde T.;Benoit, Danielle S. W.
尽管在骨科应用中广泛使用常规诊断方法，但在检测和诊断许多病理方面仍然存在局限性，特别是在干预最关键的早期阶段。使用生物材料来开发诊断和治疗诊断学，包括用于全身或局部应用的纳米颗粒和支架，对于解决这些缺点并实现成功的临床转化具有重要的前景。诊断和治疗诊断生物材料的模块化和整体设计的这些发展可能会改善从癌症到骨折到感染的无数骨科应用的患者治疗。
Despite widespread use of conventional diagnostic methods in orthopedic applications, limitations still exist in detection and diagnosing many pathologies, especially at early stages when intervention is most critical. The use of biomaterials to develop diagnostics and theranostics, including nanoparticles and scaffolds for systemic or local applications, has significant promise to address these shortcomings and enable successful clinical translation. These developments in both modular and holistic design of diagnostic and theranostic biomaterials may improve patient treatments for myriad orthopedic applications ranging from cancer to fractures to infection.