Visceral adiposity index and 10-year cardiovascular disease incidence: The ATTICA study
Visceral adiposity index and 10-year cardiovascular disease incidence: The ATTICA study
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DOI：
10.1016/j.numecd.2017.06.015
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发表时间：
2017-10-01
影响因子：
3.9
通讯作者：
Pitsavos, C.
中科院分区：
文献类型：
--
作者：
Kouli, G. -M.;Panagiotakos, D. B.;Pitsavos, C.
背景和目的：内脏脂肪指数（VAI）已被提出作为内脏脂肪组织积聚/功能障碍的标志物。我们的目的是评估VAI和10年心血管疾病（CVD）发病率之间的潜在联系。方法和结果：2001-2002年期间，3042名希腊成年人（1514名男性;年龄：>= 18岁），既往无CVD，被招募到ATTICA研究中，而10年的研究随访在2011-2012年进行，记录2020年（1010名男性）受试者的致死性/非致死性CVD发病率。这些参与者的基线VAI评分是基于人体测量和血脂变量计算的，同时提取VAI三分位数进行进一步分析。在研究随访期间，共观察到317起CVD事件（15.7%）。基线时，参与者的年龄和高血压、糖尿病、高胆固醇血症和代谢综合征的患病率在VAI三分位数中显著增加。在调整了多种混杂因素后，VAI与10年CVD发病率呈显著独立正相关（OR = 1.05，95%CI：1.01，1.10），而体重指数与（HR = 1.03，95% CI：0.99，1.08）或腰围（HR = 1.01，95% CI：0.99，1.02）不太显著。性别特异性分析进一步表明，VAI在单独的男性中仍然显著预测CVD（HR = 1.06，95% CI：1.00，1.11），但在女性中并非如此（HR = 1.06，95% CI：0.96，1.10）。我们的研究结果首次在一个大样本，长期，欧洲的一项前瞻性研究表明，VAI与10年CVD风险升高独立相关，尤其是男性。这表明，VAI可以作为一个额外的指标，长期CVD风险的高加索/地中海男性没有以前的CVD。(C)2017年意大利糖尿病学会，意大利动脉粥样硬化研究学会，意大利人类营养学会，以及Federico II大学临床医学和外科学系。Elsevier B. V.出版，保留所有权利。
Background and aims: Visceral adiposity index (VAI) has been proposed as a marker of visceral adipose tissue accumulation/dysfunction. Our aim was to evaluate potential associations between the VAI and the 10-year cardiovascular disease (CVD) incidence.Methods and results: During 2001-2002, 3042 Greek adults (1514 men; age: >= 18 years) without previous CVD were recruited into the ATTICA study, whilst the 10-year study follow-up was performed in 2011-2012, recording the fatal/non-fatal CVD incidence in 2020 (1010 men) participants. The baseline VAI scores for these participants were calculated based on anthropometric and lipid variables, while VAI tertiles were extracted for further analyses. During the study follow-up a total of 317 CVD events (15.7%) were observed. At baseline, the participants' age and the prevalence of hypertension, diabetes, hypercholesterolemia and metabolic syndrome increased significantly across the VAI tertiles. After adjusting for multiple confounders, VAI exhibited a significantly independent positive association with the 10-year CVD incidence (OR = 1.05, 95% CI: 1.01, 1.10), whereas the association of the body mass index (HR = 1.03, 95% CI: 0.99, 1.08), or the waist circumference (HR = 1.01, 95% CI: 0.99, 1.02) was less prominent. Sex-specific analysis further showed that VAI remained significantly predictive of CVD in men alone (HR = 1.06, 95% CI: 1.00, 1.11) but not in women (HR = 1.06, 95% CI: 0.96, 1.10).Conclusions: Our findings show for the first time in a large-sample, long-term, prospective study in Europe that the VAI is independently associated with elevated 10-year CVD risk, particularly in men. This suggests that the VAI may be utilized as an additional indicator of long-term CVD risk for Caucasian/Mediterranean men without previous CVD. (C) 2017 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.