Subcutaneous‐PCA: An Alternative to IV‐PCA for Postoperative Pain Management
Subcutaneous‐PCA: An Alternative to IV‐PCA for Postoperative Pain Management
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皮下 PCA：术后疼痛管理的 IV-PCA 替代方案
DOI：
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发表时间：
1990
期刊：
影响因子：
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通讯作者：
P. White
中科院分区：
文献类型：
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作者：
P. White
接受重大骨科手术（例如全髋关节置换术）的患者 (n - 120)。泌尿科（例如根治性前列腺切除术）或妇科（例如全腹部子宫切除术）手术被随机分配为术后使用患者自控镇痛（PCA）输送系统接受吗啡或羟吗啡酮。在 72 小时的研究期间，阿片类镇痛剂通过静脉注射 (IV-PCA) 或皮下注射 (SQ-PCA) 给药。羟吗啡酮。 0.6？ /Mp 0.42 毫克/小时（0-24 小时）。 0.53 /Mp 0.35 mg/h（24-48 小时）和 0.42 /Mp 0.31 mg/h（48-72 小时）与吗啡一样有效。 2.2 /Mp 1.6 mg/h（0-24 小时）、1.6 /Mp 1.2 mg/h（24-48 小时）和 1.2 /Mp 1.1 mg/h（48-72 小时），可缓解术后疼痛（平均值/Mp SD）。尽管 SQ-PCA 的平均阿片类药物剂量需求高出 10 至 28/X%。它是传统 IV-PCA 的可接受替代方案，用于控制大型外科手术后的疼痛。所有四个 PCA 治疗组的术后镇痛评分和患者满意度相似。因此。 SQ-PCA 联合羟吗啡酮或吗啡代表了临床上可接受的 IV-PCA 治疗术后疼痛的替代方案。
Patients (n - 120) undergoing major orthopedic (e.g.. total hip replacement). urologic (e.g.. radical prostatectomy), or gynecologic (e.g.. total abdominal hysterectomy) procedures were randomly assigned to receive either morphine or oxymorphone postoperatively using a patient-controlled analgesic (PCA) delivery system. The opioid analgesic was administered either intravenously (IV-PCA) or subcutaneously (SQ-PCA) during the 72-h study period. Oxymorphone. 0.6? /Mp 0.42 mg/h (0–24 h). 0.53 /Mp 0.35 mg/h (24–48 h),'and 0.42 /Mp 0.31 mg/h (48–72 h), was as effective as morphine. 2.2 /Mp 1.6 mg/h (0–24 h), 1.6 /Mp 1.2 mg/h (24–48 h), and 1.2 /Mp 1.1 mg/h (48–72 h), in providing postoperative pain relief (mean values /Mp SD). Although the average opioid dosage requirements were 10 to 28/X% higher with SQ-PCA. it is an acceptable alternative to conventional IV-PCA for pain control after major surgical procedures. Postoperative analgesia scores and patient satisfaction were similar in all four PCA treatment groups. Thus. SQ-PCA with either o.xymorphone or morphine represents a clinically acceptable alternative to IV-PCA in the treatment of postoperative pain.