Experimental systemic infection with Cryptococcus neoformas var. grubii and Cryptococcus gattii in normal and immunodeficient mice
Experimental systemic infection with Cryptococcus neoformas var. grubii and Cryptococcus gattii in normal and immunodeficient mice
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DOI：
10.1080/13693780600810040
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发表时间：
2006-11-01
期刊：
影响因子：
2.9
通讯作者：
Stevens, David A.
中科院分区：
文献类型：
--
作者：
Capilla, Javier;Maffei, Claudia M. L.;Stevens, David A.
新型隐球菌 (Cn) 变种grubii 或新型隐球菌变种。新型隐球菌感染通常与免疫功能低下的宿主有关，而格特隐球菌更常在免疫功能正常的宿主中引起疾病。我们研究了免疫缺陷和糖皮质激素诱导的免疫抑制对静脉注射诱导的全身性小鼠感染的影响。接种这些病原体。 SCID 和免疫活性 BALB/c 和 C57BL/6 小鼠感染
Cryptococcus neoformans (Cn) var. grubii or Cryptococcus neoformans var. neoformans infection is usually associated with immunocompromised hosts, whereas Cryptococcus gattii more frequently causes disease in immunocompetent hosts. We examined the effects of immunodeficiency and glucocorticoid- induced immunosuppression on systemic murine infection induced by i.v. inoculation with these pathogens. SCID and immunocompetent BALB/c and C57BL/6 mice were infected with