Curcumin ameliorated dextran sulfate sodium-induced colitis via regulating the homeostasis of DCs and Treg and improving the composition of the gut microbiota
Curcumin ameliorated dextran sulfate sodium-induced colitis via regulating the homeostasis of DCs and Treg and improving the composition of the gut microbiota
复制标题
姜黄素通过调节 DC 和 Treg 的稳态以及改善肠道微生物群的组成来改善右旋糖酐硫酸钠诱导的结肠炎
DOI：
10.1016/j.jff.2021.104716
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发表时间：
2021-09-01
影响因子：
5.6
通讯作者：
Liu，Duan-Yong
中科院分区：
文献类型：
--
作者：
Zhong，You-Bao;Kang，Zeng-Ping;Liu，Duan-Yong
异常树突状细胞（dc）和Treg细胞极化和肠道菌群失调是炎症性肠病（IBD）发病机制的典型特征。天然化合物姜黄素具有良好的抗炎特性。然而，姜黄素是否通过调节dc、Treg和肠道微生物群的稳态来有效改善IBD尚不清楚。本研究采用姜黄素（100 mg/kg/d）口服硫酸葡聚糖钠致小鼠结肠炎7 d。结肠重指数显著降低，体重、结肠重、结肠长度和结肠组织损伤显著改善；Treg比例显著升高，炎性dc和促炎性细胞因子显著降低，肠道菌群组成改善。此外，姜黄素抑制结肠炎小鼠PI3K/Akt信号通路的激活。这些数据表明，姜黄素通过调节dc、Treg和肠道微生物群改善结肠炎，其潜在机制与抑制PI3K/Akt通路有关。
Abnormal dendritic cells (DCs) and Treg cell polarisation and dysbiosis of the intestinal flora are typical features of the pathogenesis of inflammatory bowel disease (IBD). The natural compound curcumin has good anti-inflammatory properties. However, it is unclear whether curcumin effectively ameliorates IBD by regulating the homeostasis of DCs, Treg and gut microbiota. In this study, mice colitis induced by dextran sulfate sodium was orally administrated with curcumin (100 mg/kg/day) for 7 days. Consequently, the index of colonic weight significantly decreased, and body weight, colonic weight, colonic length and colonic tissue injury improved significantly; the percentage of Treg increased significantly, inflammatory DCs and pro-inflammatory cytokines decreased significantly, and the composition of gut microbiota were improved. In addition, curcumin inhibited the activation of PI3K/Akt signaling pathway in colitis mice. These data suggested that curcumin ameliorated colitis by regulating DCs, Treg and gut microbiota, and the underlying mechanism is related to PI3K/Akt pathway inhibition.