Increased fluid intake does not augment capacity to lay down new collagen in nursing home residents at risk for pressure ulcers: a randomized, controlled clinical trial.
Increased fluid intake does not augment capacity to lay down new collagen in nursing home residents at risk for pressure ulcers: a randomized, controlled clinical trial.
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增加液体摄入量并不会增强有压疮风险的疗养院居民产生新胶原蛋白的能力：一项随机对照临床试验。
DOI：
10.1111/j.1524-475x.2009.00539.x
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Wu,Horng-Shiuann
中科院分区：
文献类型：
--
作者：
Stotts,NancyA;Hopf,HarrietW;Kayser-Jones,Jeanie;Chertow,GlennM;Cooper,BruceA;Wu,Horng-Shiuann
预防压疮是安全护理疗养院居民的基础，但水化在预防压疮中的作用尚未得到系统的研究。这项随机临床试验旨在确定对有压疮风险的疗养院居民给予补充液体是否会增强胶原蛋白沉积，增加估计的全身水分，增加皮下组织氧合，并且是安全的。基线期后，64例受试者随机接受规定的液体体积或额外液体（规定加10 mL/kg），持续5天。 用羟脯氨酸测量的参与者的愈合潜力在基线时较低，并且当系统地提供额外的液体时，在治疗期间没有显著增加。治疗期间液体摄入量显著增加。全身水分和皮下氧的估计值没有增加，表明水合作用没有改善。根据临床参数测量，补充液体未导致过度水合。需要进一步的工作来研究疗养院居民的液体摄入量和水合作用之间的关系，以及水合作用在压疮预防中的作用。
Prevention of pressure ulcers is fundamental to safe care of nursing home residents yet the role of hydration in pressure ulcer prevention has not been systematically examined. This randomized clinical trial was undertaken to determine whether administration of supplemental fluid to nursing home residents at risk for pressure ulcers would enhance collagen deposition, increase estimated total body water, augment subcutaneous tissue oxygenation, and was safe. After a baseline period, 64 subjects were randomized to receive the fluid volume prescribed or additional fluid (prescribed plus 10 mL/kg) for 5 days. Participants' potential to heal as measured with hydroxyproline was low at baseline and did not increase significantly during treatment when additional fluid was systematically provided. Fluid intake increased significantly during treatment. Estimates of total body water and subcutaneous oxygen did not increase, indicating hydration was not improved. Supplemental fluid did not result in overhydration as measured by clinical parameters. Further work is needed to examine the relationship between fluid intake and hydration in nursing home residents as well as the role of hydration in pressure ulcer prevention.