Optical coherence elastography of bilayer soft tissue based on harmonic surface wave spectroscopy
Optical coherence elastography of bilayer soft tissue based on harmonic surface wave spectroscopy
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DOI：
10.1016/j.optlaseng.2021.106667
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发表时间：
2021-05-13
影响因子：
4.6
通讯作者：
Sun, Cuiru
中科院分区：
文献类型：
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作者：
Chen, Jinlong;Hu, Yongzheng;Sun, Cuiru
疾病往往起源于生物组织的某一层，因此同时测量各层弹性模量对各种疾病的早期诊断和治疗具有重要意义。提出了一种基于谐波激励的表面波光谱（SWS）光学相干弹性成像（OCE）技术。设计了一种由带引脚的压电堆构成的致动器，用于产生谐波表面波。提出了一种b模OCT数据采集和相位分析方法，对波形进行成像，并计算表面波速。用不同的频率激发样品，得到表面波色散曲线。针对弹性模量沿深度的分布，提出了一种全变分正则化迭代算法。通过有限元仿真和实验测量验证了该方法的有效性。基于机械驱动谐波驱动的OCE方法在实验装置上简单、经济。基于b模OCT扫描，数据分析速度非常快，可以实现实时弹性成像。本研究为层状组织的生物力学特性研究提供了一种有效的方法。
Diseases often initiate from a certain layer of the biological tissue, thus simultaneous measurement of the elastic modulus of each layer is important for early diagnosis and treatment of various diseases. A surface wave spectroscopy (SWS) optical coherence elastography (OCE) technique based on harmonic wave excitation was proposed. An actuator consisting of a piezoelectric stack with a pin was designed to generate harmonic surface waves. A B-mode OCT data acquisition and phase analysis method was proposed to image the wave forms, and calculate the surface wave velocity. By exciting the sample with different frequencies, the surface wave dispersion curves were obtained. A total variation (TV) regularization iterative algorithm was proposed to obtain the elastic modulus distribution along the depth. Effectiveness of the proposed method was evaluated by both finite element simulation and experimental measurement of a bi-layer phantom. The mechanically driven harmonic wave actuation based OCE method is simple and cost-effective in experimental setup. Based on B-mode OCT scans, data analysis can be very fast, which is possible to realize real-time elastography imaging. This study provides an effective method for biomechanical properties study of layered tissue.