Methadone dosage and retention: An examination of the 60 mg/Day threshold
Methadone dosage and retention: An examination of the 60 mg/Day threshold
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DOI：
10.1300/j069v24n03_03
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发表时间：
2005-01-01
影响因子：
2.3
通讯作者：
Yu, P
中科院分区：
文献类型：
--
作者：
Brady, TA;Salvucci, S;Yu, P
美国国立卫生研究院（NIH）专家小组曾提到，每日至少60毫克的美沙酮剂量是美沙酮维持的最佳做法。本研究的重点是估计接受该水平美沙酮的门诊美沙酮患者的百分比，并检查治疗保留与美国国立卫生研究院专家组推荐的美沙酮剂量水平之间的关系。本研究使用了酒精和药物服务研究（ADSS）中从美沙酮治疗机构出院的428名美沙酮客户样本，代表了全国109,973名美沙酮客户。据估计，全国超过三分之二的美沙酮患者每日服用剂量低于60毫克。在控制了一些客户和组织变量的情况下，发现每日60mg /天或以上的美沙酮剂量与更长的治疗保留时间有关。探索影响每日美沙酮推荐剂量使用的因素仍然是美沙酮治疗有效交付的重要问题。
A National Institutes of Health (NIH) expert panel has mentioned a daily methadone dose of at least 60 mg as a best practice in methadone maintenance. The focus of this research is to estimate the percentage of outpatient methadone clients receiving this level of methadone and examine the association between treatment retention and level of methadone dosage as recommended by the NIH expert panel. A sample of 428 methadone clients discharged from methadone treatment facilities from the Alcohol and Drug Services Study (ADSS) was used, representing 109,973 methadone clients nationally. It was estimated that more than two-thirds of methadone clients nationally were receiving below 60 mg/day. While controlling for a number of client and organizational variables, a daily methadone dose of 60 mg/day or above was found to be associated with longer retention in treatment. Exploring factors affecting the utilization of the recommended daily methadone dose remains an important issue in effective delivery of methadone treatment.