How Could SNARE Proteins Open a Fusion Pore?
How Could SNARE Proteins Open a Fusion Pore?
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DOI：
10.1152/physiol.00026.2013
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发表时间：
2014-07-01
期刊：
影响因子：
8.4
通讯作者：
Lindau, Manfred
中科院分区：
文献类型：
--
作者：
Fang, Qinghua;Lindau, Manfred
在哺乳动物神经分泌细胞中，SNARE（可溶性NSF附着蛋白受体）复合物由synaptobrevin 2（也称为VAMP2）、syntaxin和SNAP-25蛋白组成，在囊泡融合中起关键作用。在这篇综述中，我们讨论了在神经分泌细胞中，融合孔的形成是由SNARE复合体的构象变化通过跨膜结构域的运动直接完成的假设。
The SNARE (Soluble NSF Attachment protein REceptor) complex, which in mammalian neurosecretory cells is composed of the proteins synaptobrevin 2 (also called VAMP2), syntaxin, and SNAP-25, plays a key role in vesicle fusion. In this review, we discuss the hypothesis that, in neurosecretory cells, fusion pore formation is directly accomplished by a conformational change in the SNARE complex via movement of the transmembrane domains.