Protective mechanisms in germ cells: stress proteins in spermatogenesis.
Protective mechanisms in germ cells: stress proteins in spermatogenesis.
复制标题
生殖细胞的保护机制：精子发生中的应激蛋白。
DOI：
10.1007/978-1-4899-0089-0_16
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发表时间：
1998
影响因子：
--
通讯作者：
R. Hong
中科院分区：
文献类型：
--
作者：
D. Dix;R. Hong
广泛的环境暴露触发生殖组织的保护机制，这是由应激或热休克蛋白（HSPs）介导的。这些应激蛋白维持正常的细胞功能，如蛋白质合成，并协助抵抗和从毒物诱导的细胞损伤中恢复。在过去的十年中，许多实验室已经研究了这些应激蛋白在配子体发生过程中的表达和潜在功能（见Dix， 1997a）和生殖毒理学（Dix, 1997b）。本文综述了热休克蛋白在睾丸中的表达，详细分析了热休克蛋白70-2在精子发生减数分裂阶段的功能，并对应激诱导热休克蛋白及其可能的保护机制进行了讨论。
A wide range of environmental exposures trigger protective mechanisms in reproductive tissues which are mediated by stress or heat shock proteins (HSPs). These stress proteins maintain normal cellular functions such as protein synthesis, as well as assist in resisting and recovering from toxicant-induced cellular damage. Over the past decade a number of laboratories have examined the expression and potential functions of these stress proteins during gametogenesis (reviewed in Dix, 1997a) and in reproductive toxicology (Dix, 1997b). This paper reviews the expression of HSPs in testes, presents a detailed analysis of the function of Hsp70-2 during the meiotic phase of spermatogenesis, and concludes with a discussion of stress-inducible HSPs and putative protective mechanisms.