Thromboembolism in inflammatory bowel disease: results from a prospective, population-based European inception cohort
Thromboembolism in inflammatory bowel disease: results from a prospective, population-based European inception cohort
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DOI：
10.3109/00365521.2014.910545
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发表时间：
2014-07-01
影响因子：
1.9
通讯作者：
Moum, Bjorn
中科院分区：
文献类型：
--
作者：
Isene, Rune;Bernklev, Tomm;Moum, Bjorn
背景炎症性肠病（IBD）患者发生静脉血栓栓塞（VTE）的风险增加，尤其是住院时。对真实风险的估计在不同研究之间差异很大，主要是由于方法学的差异。我们着手确定一个以人群为基础的欧洲初始队列中静脉血栓栓塞的发病率。方法. IBD患者被纳入一个队列，从20世纪90年代初到21世纪初进行前瞻性随访。共对1145例患者进行了10，634患者年（p.y.）的随访。结果共确定了19例血栓栓塞事件- 13例深静脉血栓形成和6例肺栓塞。VTE的发病率为1.8/1000 p.y.。结论该IBD队列中VTE的风险升高，但低于先前报告的风险。住院患者的风险最高，但门诊患者中需要皮质类固醇的疾病也有一定的风险。
Background. Patients with inflammatory bowel disease (IBD) have proven an increased risk of venous thromboembolism (VTE), particularly when hospitalized. The estimate of the true risk varies considerably between studies, primarily due to differences in methodology. We set out to determine the incidence of VTE in a population-based European inception cohort. Methods. IBD patients were incepted into a cohort that was prospectively followed from the early 1990s to the early 2000s. A total of 1145 patients were followed for a total of 10,634 patient-years (p.y.). Results. A total of 19 thromboembolic events were identified - 13 deep vein thrombosis and 6 with pulmonary embolism. The incidence rate of VTE was 1.8 per 1000 p.y. Conclusion. The risk of VTE was elevated in this IBD cohort but lower than previously reported. The highest risk was seen in hospitalized patients, but corticosteroids-requiring disease in outpatients also conferred some risk.