MOUSE MAMMARY-TUMORS - ALTERATION OF INCIDENCE AS APPARENT FUNCTION OF STRESS
MOUSE MAMMARY-TUMORS - ALTERATION OF INCIDENCE AS APPARENT FUNCTION OF STRESS
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DOI：
10.1126/science.168638
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发表时间：
1975-01-01
期刊：
影响因子：
56.9
通讯作者：
RILEY, V
中科院分区：
文献类型：
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作者：
RILEY, V
在通常的饲养和实验条件下进行研究时，携带Bittner致癌病毒的C3H/He品系的雌性小鼠中，80%到100%的小鼠通常在出生后8到18个月内患上乳腺肿瘤。通过将不同组的此类小鼠置于提供不同程度慢性应激的环境环境中，400天的乳腺肿瘤发病率得到了改变，在应激状态下的发病率从92%到在受保护环境中的7%不等。这些数据表明，适度的慢性或间歇性应激可能会使这些小鼠患乳腺癌的风险增加，这可能是因为它们的免疫能力或肿瘤监测系统受到了损害，而充分的生理应激保护可能会减少小鼠乳腺癌的发生。
Eighty to 100 percent of female mice of the C3H/He strain carrying the Bittner oncogenic virus usually develop mammary tumors within 8 to 18 months after birth when studied under the usual housing and experimental conditions. By subjecting various groups of such mice to environmental circumstances providing different degrees of chronic stress, mammary tumor incidence at 400 days was modified, with incidences ranging from 92 percent under stress to 7 percent in a protected environment. The data suggest that moderate chronic or intermittent stress may predispose such mice to an increased risk of mammary carcinoma, possibly through a resultant compromise of their immunological competence or tumor surveillance system, and that adequate protection from physiological stress may reduce mammary tumor occurrence in mice.