Cytokine gene associations with self-report ratings of morning and evening fatigue in oncology patients and their family caregivers.
Cytokine gene associations with self-report ratings of morning and evening fatigue in oncology patients and their family caregivers.
复制标题
DOI：
10.1177/1099800414534313
复制
发表时间：
2015-03
影响因子：
2.5
通讯作者：
Miaskowski C
中科院分区：
文献类型：
--
作者：
Dhruva A;Aouizerat BE;Cooper B;Paul SM;Dodd M;West C;Wara W;Lee K;Dunn LB;Langford DJ;Merriman JD;Baggott C;Cataldo J;Ritchie C;Kober KM;Leutwyler H;Miaskowski C
本研究的目的是评估被分类为早晚疲劳水平较低和较高的参与者之间促炎和抗炎细胞因子基因变异的差异，并评估这两组之间表型特征的差异。在 167 名患有乳腺癌、前列腺癌、肺癌或脑癌的肿瘤科门诊患者及其 85 名家庭护理人员的样本中，使用生长混合模型 (GMM) 根据放射治疗之前、期间和完成后 4 个月内获得的早晚疲劳评级来识别个体的潜在类别。评估了潜在类别之间 15 个细胞因子基因的单核苷酸多态性 (SNP) 和单倍型的差异。使用多元逻辑回归来评估表型和基因型特征对早晨和晚上疲劳等级成员的影响。研究发现早晨疲劳与合并症数量以及 TNFA rs1800629 和 rs3093662 的变异之间存在关联。夜间疲劳与在家照顾孩子以及 IL4 rs2243248 和 TNFA rs2229094 的变异有关。较小的年龄和较低的表现状态与早晨和晚上的疲劳有关。这些发现表明炎症介质与早晚疲劳的发生有关。然而，由于不同的表型特征和基因组标记与疲劳的昼夜变化相关，因此早晨和晚上的疲劳可能是不同但相关的症状。
The purpose of this study was to evaluate for differences in variations in pro- and anti-inflammatory cytokine genes between participants who were classified as having low and high levels of morning and evening fatigue and to evaluate for differences in phenotypic characteristics between these two groups. In a sample of 167 oncology outpatients with breast, prostate, lung, or brain cancer and 85 of their family caregivers, growth mixture modeling (GMM) was used to identify latent classes of individuals based on ratings of morning and evening fatigue obtained prior to, during, and for 4 months following completion of radiation therapy. Differences in single nucleotide polymorphisms (SNPs) and haplotypes in 15 cytokine genes were evaluated between the latent classes. Multiple logistic regression was used to assess the effect of phenotypic and genotypic characteristics on morning and evening fatigue class membership. Associations were found between morning fatigue and number of comorbidities as well as variations in TNFA rs1800629 and rs3093662. Evening fatigue was associated with caring for children at home and variations in IL4 rs2243248 and TNFA rs2229094. Younger age and lower performance status was associated with both morning and evening fatigue. These findings suggest that inflammatory mediators are associated with the development of morning and evening fatigue. However, because different phenotypic characteristics and genomic markers are associated with diurnal variations in fatigue, morning and evening fatigue may be distinct but related symptoms.