MicroRNA transport in cardiovascular complication of diabetes
MicroRNA transport in cardiovascular complication of diabetes
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DOI：
10.1016/j.bbalip.2016.01.010
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发表时间：
2016-12-01
影响因子：
4.8
通讯作者：
Emanueli, Costanza
中科院分区：
文献类型：
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作者：
Caporali, Andrea;Miscianinov, Vladislav;Emanueli, Costanza
微小RNA（miRNAs）是通过与互补信使RNA（mRNA）转录物结合而对基因表达进行转录后抑制性调节的分子.细胞外miRNA通过膜衍生的囊泡（外来体和微粒）、脂蛋白和其他核糖核蛋白复合物转运。细胞外microRNA是细胞间通讯的重要介质，参与细胞间生物信号的传递。几种miRNA已被鉴定为对与糖尿病的心血管并发症直接相关的许多生物过程具有主要影响。细胞外miRNAs是否直接参与这些过程的调控尚待确定。本文综述了细胞外miRNA生物学的最新研究进展，以及细胞外miRNA在糖尿病心血管疾病中的作用，阐述了影响miRNA转运的调节因子以及不同miRNA转运蛋白的作用机制。此外，我们讨论了在这一领域的研究进展，并确定相关的挑战。这篇文章是由卡洛斯费尔南德斯-埃尔南多和亚杰拉苏亚雷斯编辑的题为“微RNA和脂质/能量代谢及相关疾病”的特刊的一部分。(C)© 2016 Elsevier B. V.版权所有。
MicroRNAs (miRNAs) are post -transcriptional inhibitory regulators of gene expression by binding to complementary messenger RNA (mRNA) transcripts. Extracellular miRNAs are transported by membrane derived vesicles (exosomes and microparticles), lipoproteins, and other ribonucleoprotein complexes. Extra cellular microRNAs are emerging as important mediators of intercellular communications, being involved in the transmission of biological signals between cells. Several miRNAs have been identified as having a primary impact on many biological processes that are of direct relevance to cardiovascular complications of diabetes. Whether the extracellular miRNAs are directly involved in the regulation of these processes is yet to be established. Here, we review recent progresses in extracellular miRNA biology and the role of extra-cellular miRNA in diabetes induced cardiovascular disease, describing the regulators affecting miRNA transport and the mechanisms for different miRNA transporters. In addition, we discuss the advancement of the research in this field and identify the associated challenges. This article is part of a Special Issue entitled: MicroRNAs and lipid/energy metabolism and related diseases edited by Carlos Fernandez-Hernando and Yajaira Suarez. (C) 2016 Elsevier B.V. All rights reserved.