Elevated aluminum persists in serum and tissues of rabbits after a six-hour infusion.
Elevated aluminum persists in serum and tissues of rabbits after a six-hour infusion.
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输注六小时后，兔子的血清和组织中铝含量持续升高。
DOI：
10.1016/0041-008x(89)90118-x
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发表时间：
1989
影响因子：
3.8
通讯作者：
McNamara,PJ
中科院分区：
文献类型：
--
作者：
Yokel,RA;McNamara,PJ
对代表性哺乳动物兔子的选定组织和体液中的铝半衰期进行了估计。单次静脉内铝输注后，通过连续杀死兔子并通过电热原子吸收光谱法对选定的组织和液体中的铝进行定量来确定半衰期。 200μmol/kg铝剂量后4小时显示出显着增加的组织和液体是胆汁、肾、肝、肺、血清和脾。在肾上腺、骨骼、心脏、肌肉、睾丸、甲状腺或选定的中枢神经系统区域中，铝浓度没有显着高于对照。输注后12小时内胆汁铝浓度恢复到控制水平。脾脏中的估计半衰期为113天，肝脏中为74天，肺中为44天，血清中为42天，肾皮质中为4.2天，肾髓质中为2.3天。肾脏还表现出另一个大大超过 100 天的半衰期。结果表明，铝在各种组织和体液中的持续时间不同。计算出的这些组织中铝的半衰期比之前根据血清铝测定估计的半衰期要长得多。铝在肝脏和其他组织中的持久存在可能是敏感靶器官（例如大脑）持续接触铝的来源。这些计算出的半衰期确定了组织中铝消除的正常速率。未来的研究可以确定尿毒症或螯合疗法等因素对储存场所和血清中铝消除率的影响。
The half-life of aluminum was estimated in selected tissues and fluids in a representative mammal, the rabbit. After a single iv aluminum infusion, half-lives were determined by serial killing of rabbits and aluminum quantitation in selected tissues and fluids by electrothermal atomic absorption spectroscopy. Tissues and fluids demonstrating a significant increase 4 hr after the 200 μmol/kg aluminum dose were the bile, kidney, liver, lung, serum, and spleen. Aluminum concentration did not significantly increase above control in the adrenal gland, bone, heart, muscle, testis, thyroid gland, or selected central nervous system regions. Biliary aluminum concentration returned to control within 12 hr after infusion. Estimated half-lives were 113 days in spleen, 74 days in liver, 44 days in lung, 42 days in serum, 4.2 days in kidney cortex, and 2.3 days in kidney medulla. The kidney also demonstrated another half-life greatly exceeding 100 days. The results demonstrate that aluminum persists in various tissues and fluids for different lengths of time. The calculated half-life of aluminum in these tissues is substantially longer than previously estimated half-lives based on serum aluminum determination. The persistence of aluminum in the liver and other tissues may serve as a source of continous aluminum exposure for sensitive target organs such as the brain. These calculated half-lives establish the normal rate of aluminum elimination from tissues. Furure studies could determine the influence of factors such as uremia or chelation therapy on the rate of aluminum elimination from storage sites as well as serum.