A case of middle-ear myoepithelioma
A case of middle-ear myoepithelioma
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DOI：
10.1016/j.otohns.2005.05.016
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发表时间：
2006-12-01
影响因子：
3.4
通讯作者：
Ishida, Tsuyoshi
中科院分区：
文献类型：
--
作者：
Hagisawa, Miho;Yamasoba, Tatsuya;Ishida, Tsuyoshi
肌上皮细胞（Myoepithelial cells，MCs）多见于外分泌腺的闰管和腺泡中的上皮细胞和基底细胞之间。1肌上皮瘤（ME）是一种具有肌上皮分化但不具有导管分化的肿瘤。这类肿瘤占所有发生在唾液腺的肿瘤的1%，1，2，并根据组织学类型分为四种类型：梭形，浆细胞样，上皮样和透明细胞。3ME被认为是来源于MC，并且由四种细胞类型中的一种单独或组合组成。ME基本上是良性的，没有不典型的核分裂像或坏死的迹象，这两种情况都可以在肌上皮癌中看到。1在这个病例中，由于其临床表现和位置，我们在术前就预期肿瘤是鼓室球瘤。然而，组织学检查显示均匀的梭形细胞增殖，这不是颈静脉鼓室血管球瘤的特征。免疫组织化学检查，上皮和平滑肌标志物均呈阳性。此外，没有染色嗜铬粒蛋白A，这通常是阳性的血管球瘤，而且没有发现神经分泌颗粒，
DISCUSSIONMyoepithelial cells (MCs) are usually seen between epithelial cells and basal cells in intercalated ducts and acini of exocrine glands. 1 Myoepithelioma (ME) is a tumor that shows myoepithelial differentiation but not ductal differentiation. Such tumors account for 1% of all tumors developing in the salivary glands, 1, 2 and are classified into four types by histological pattern: spindle, plasmacytoid, epithelioid, and clear cells. 3 ME is considered to derive from MCs and consists of one of the four cell types alone or in combination. ME is basically benign without atypical mitotic figures or signs of necrosis, either of which may be seen in myoepithelial carcinoma. 1 In this case, we had anticipated that the tumor would be a glomus tympanic tumor preoperatively because of its clinical findings and location. However, histological examination demonstrated proliferation of uniform spindle cells, which is not the feature of jugulotympanic glomus tumor. On immunohistochemical examination, both epithelial and smooth muscle markers were positive. In addition, there was no staining for chromogranin A, which is usually positive in a glomus tumor, and moreover there were no neurosecretory granules found by