Combined ventricular systolic and arterial stiffening in patients with heart failure and preserved ejection fraction - Implications for systolic and diastolic reserve limitations
Combined ventricular systolic and arterial stiffening in patients with heart failure and preserved ejection fraction - Implications for systolic and diastolic reserve limitations
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DOI：
10.1161/01.cir.0000048123.22359.a0
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发表时间：
2003-02-11
期刊：
影响因子：
37.8
通讯作者：
Kass, DA
中科院分区：
文献类型：
--
作者：
Kawaguchi, M;Hay, I;Kass, DA
射血分数保留性心力衰竭（HF-nlEF）在老年收缩期高血压患者中很常见，通常归因于舒张功能障碍。我们假设，这样的患者还显示结合心室收缩和动脉硬化，可以加剧血压不稳定和舒张功能障碍stress.Methods和Results-Left心室压力-容积关系测定HF-nLEF（n=10）患者和对比无症状的年龄匹配（n=9）和年轻（n=14）血压正常和年龄和血压匹配的对照组（n=25）。HF-nIEF患者的收缩末期弹性（僵硬度）（4.7 ± 1.5 mm Hg/mL）高于对照组（血压正常者为2.1 ± 0.9 mm Hg/mL，高血压者为3.3 ± 1.0 mm Hg/mL; P
Background-Heart failure with preserved ejection fraction (HF-nlEF) is common in aged individuals with systolic hypertension and is frequently ascribed to diastolic dysfunction. We hypothesized that such patients also display combined ventricular-systolic and arterial stiffening that can exacerbate blood pressure lability and diastolic dysfunction under stress.Methods and Results-Left ventricular pressure-volume relations were measured in patients with HF-nlEF (n=10) and contrasted with asymptomatic age-matched (n=9) and young (n=14) normotensives and age- and blood pressure-matched controls (n=25). End-systolic elastance (stiffness) was higher in patients with HF-nlEF (4.7+/-1.5 mm Hg/mL) than in controls (2.1+/-0.9 mm Hg/mL for normotensives and 3.3+/-1.0 mm Hg/mL for hypertensives; P