Lupus and Epstein-Barr.
Lupus and Epstein-Barr.
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DOI：
10.1097/bor.0b013e3283535801
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发表时间：
2012-07
影响因子：
5.1
通讯作者：
Robertson JM
中科院分区：
文献类型：
--
作者：
James JA;Robertson JM
系统性红斑狼疮 (SLE) 是一种异质性人类疾病，受必要因素复杂相互作用的影响，但单个因素并不充分。尽管许多遗传和环境因素与 SLE 相关，但本综述将重点关注 Epstein-Barr 病毒 (EBV) 在 SLE 中关键特异性作用的不断变化的证据，重点关注 2009 年、2010 年和 2011 年发表的新实验研究。SLE 患者对 EBV 的免疫反应失调。 EBV 抗原表现出与常见 SLE 抗原的结构分子模拟和与关键免疫调节成分的功能分子模拟。来自许多独特地理区域的 SLE 患者显示出较高的 EBV 血清转化率，尤其是针对早期 EBV 抗原，这表明病毒频繁重新激活。 SLE 患者的 EBV 病毒载量也增加，EBV 特异性 CD8+ 细胞毒性 T 细胞受损，狼疮患者对 EBV 的细胞因子反应受损。还证实了 EBV 刺激后浆细胞样树突状细胞和 CD69+ CD4+ T 细胞中细胞因子的产生不规则。最近的进展证明了 SLE 特异性血清学反应、基因表达、病毒载量、T 细胞反应、体液精细特异性以及 EBV 的分子模拟，进一步支持 EBV 在狼疮病因学和发病机制中的潜在作用。
Systemic lupus erythematosus (SLE) is a heterogeneous human disease influenced by a complex interplay of necessary, but not individually sufficient, factors. Although many genetic and environmental factors are associated with SLE, this review will focus on the evolving evidence for key Epstein-Barr virus (EBV)-specific roles in SLE, focusing on new experimental studies published during 2009, 2010, and 2011. SLE patients have a dysregulated immune response against EBV. EBV antigens exhibit structural molecular mimicry with common SLE antigens and functional molecular mimicry with critical immune-regulatory components. SLE patients, from a number of unique geographic regions, are shown to have higher rates of EBV seroconversion, especially against early EBV antigens, suggesting frequent viral reactivation. SLE patients also have increased EBV viral loads and impaired EBV-specific CD8+ cytotoxic T cells, with impaired cytokine responses to EBV in lupus patients. Irregular cytokine production in plasmacytoid dendritic cells and CD69+ CD4+ T cells after stimulation with EBV has also been demonstrated. Recent advances demonstrate SLE-specific serologic responses, gene expression, viral load, T-cell responses, humoral fine specificity, and molecular mimicry with EBV, further supporting potential roles for EBV in lupus etiology and pathogenesis.