Modification of the response to opioid and nonopioid drugs by chronic opioid antagonist treatment.
Modification of the response to opioid and nonopioid drugs by chronic opioid antagonist treatment.
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通过长期阿片拮抗剂治疗改变对阿片类药物和非阿片类药物的反应。
DOI：
10.1016/0024-3205(88)90034-3
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发表时间：
1988
期刊：
影响因子：
6.1
通讯作者：
Inturrisi,CE
中科院分区：
文献类型：
--
作者：
Yoburn,BC;Inturrisi,CE
长期暴露于阿片类拮抗剂会增加阿片类药物（如吗啡）的镇痛作用。在目前的研究中，吗啡的镇痛效力增加（超敏性）后，8天皮下纳洛酮植入小鼠，但不后1天植入。超敏反应在植入8天后的24小时达到最大，并线性下降，到120小时恢复到对照水平。纳洛酮丸植入8天，发现增加美沙酮的相对镇痛效力120%，而可卡因的致死效力略有（19%），但显着，下降。相比之下，相同的治疗没有改变苯二氮卓类药物阿普唑仑诱导共济失调的效力。
Chronic exposure to opioid antagonists increases the analgesic actions of opioids such as morphine. In the present studies, morphine's analgesic potency was increased (supersensitivity) following an 8 day subcutaneous naltrexone implant in mice, but not following a 1 day implant. Supersensitivity was maximal 24hr following the 8 day implant and declined linearty and had returned to control levels by 120hr. Implantation of naltrexone pellets for 8 days was found to increase the relative analgesic potency of methadone by 120%, while the lethal potency of cocaine was slightly (19%), but significantly, decreased. In contrast, identical treatment did not alter the potency of the benzodiazepine alprazolam to induce ataxia.