THE POPCORN WOLBACHIA INFECTION OF DROSOPHILA MELANOGASTER: CAN SELECTION ALTER WOLBACHIA LONGEVITY EFFECTS?
THE POPCORN WOLBACHIA INFECTION OF DROSOPHILA MELANOGASTER: CAN SELECTION ALTER WOLBACHIA LONGEVITY EFFECTS?
复制标题
DOI：
10.1111/j.1558-5646.2009.00745.x
复制
发表时间：
2009-10-01
期刊：
影响因子：
3.3
通讯作者：
Hoffmann, Ary A.
中科院分区：
文献类型：
--
作者：
Carrington, Lauren B.;Leslie, Jane;Hoffmann, Ary A.
沃尔巴克氏体爆米花（wMelPop），沃尔巴克氏体的一种缩短寿命的菌株，已经被提出作为抑制登革热在媒介蚊子埃及伊蚊（Aedes aegypti）感染后传播的药剂。然而，宿主和沃尔巴克氏体基因组的进化变化可能会减弱wMelPop介导的任何寿命效应。在这里，我们测试的衰减，选择菌株的果蝇感染wMelPop的早期和晚期繁殖在三个独立的异交人群。选择导致了品系间寿命的分化。这种差异主要与宿主的遗传背景有关，而不是沃尔巴克氏体感染，尽管宿主和沃尔巴克氏体基因组之间也存在相互作用。发育时间、生存力和生产力不受选择的影响。这些结果的影响进行了讨论，在光的预期用途的wMelPop抑制疾病传播。
Wolbachia popcorn (wMelPop), a life-shortening strain of Wolbachia, has been proposed as an agent for suppressing transmission of dengue fever following infection of the vectoring mosquito Aedes aegypti. However, evolutionary changes in the host and Wolbachia genomes might attenuate any life span effects mediated by wMelPop. Here we test for attenuation by selecting strains of Drosophila melanogaster infected with wMelPop for early and late reproduction in three independent outcrossed populations. Selection caused divergence among the lines in longevity. This divergence was mostly associated with the host genetic background rather than the Wolbachia infection, although there were also interactions between the host and Wolbachia genomes. Development time, viability, and productivity were not altered by selection. The implications of these results are discussed in light of the intended use of wMelPop for suppressing disease transmission.