Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults
Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults
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DOI：
10.1056/nejm199901073400103
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发表时间：
1999-01-07
影响因子：
158.5
通讯作者：
Wolfson, SK
中科院分区：
文献类型：
--
作者：
O'Leary, DH;Polak, JF;Wolfson, SK
背景颈动脉内膜和中膜的厚度与心血管疾病的患病率相关。我们研究了颈动脉内膜和中膜的厚度和新发心肌梗死或中风的发病率之间的关系，在没有临床cardiovascular diseases.Methods无创测量的内膜和中膜的共同和颈内动脉的高分辨率超声在5858名65岁或以上的受试者。心血管事件（新的心肌梗死或中风）作为无临床心血管疾病的受试者（4476例受试者）的结果变量，中位随访期为6.2 years.Results心血管事件的发生率与颈动脉内膜中层厚度的测量值相关。心肌梗死或脑卒中的相对危险性随着内膜中层厚度的增加而增加（P
Background The combined thickness of the intima and media of the carotid artery is associated with the prevalence of cardiovascular disease. We studied the associations between the thickness of the carotid-artery intima and media and the incidence of new myocardial infarction or stroke in persons without clinical cardiovascular disease.Methods Noninvasive measurements of the intima and media of the common and internal carotid artery were made with high-resolution ultrasonography in 5858 subjects 65 years of age or older. Cardiovascular events (new myocardial infarction or stroke) served as outcome variables in subjects without clinical cardiovascular disease (4476 subjects) over a median follow-up period of 6.2 years.Results The incidence of cardiovascular events correlated with measurements of carotid-artery intima-media thickness. The relative risk of myocardial infarction or stroke increased with intima-media thickness (P