The essential role of guinea pig cytomegalovirus (GPCMV) IE1 and IE2 homologs in viral replication and IE1-mediated ND10 targeting.
The essential role of guinea pig cytomegalovirus (GPCMV) IE1 and IE2 homologs in viral replication and IE1-mediated ND10 targeting.
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豚鼠巨细胞病毒 (GPCMV) IE1 和 IE2 同源物在病毒复制和 IE1 介导的 ND10 靶向中的重要作用。
DOI：
10.1016/j.virol.2017.01.023
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
McGregor,Alistair
中科院分区：
文献类型：
--
作者：
Hornig,Julia;Choi,KYeon;McGregor,Alistair
Guinea pig cytomegalovirus (GPCMV) immediate early proteins, IE1 and IE2, demonstrated structural and functional homologies with human cytomegalovirus (HCMV). GPCMV IE1 and IE2 co-localized in the nucleus with each other, the viral polymerase and guinea pig ND10 components (gpPML, gpDaxx, gpSp100, gpATRX). IE1 showed direct interaction with ND10 components by immunoprecipitation unlike IE2. Additionally, IE1 protein disrupted ND10 bodies. IE1 mutagenesis mapped the nuclear localization signal to the C-terminus and identified the core domain for gpPML interaction. Individual knockout of GPCMVGP122orGP123(IE2 and IE1 unique exons respectively) was lethal to the virus. However, an IE1 mutant (codons 234–474 deleted), was viable with attenuated viral growth kinetics and increased susceptibility to type I interferon (IFN-I). In HCMV, the IE proteins are important T cell target antigens. Consequently, characterization of the homologs in GPCMV provides a basis for their evaluation in candidate vaccines against congenital infection.
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影响因子：
8
作者：
Mitchell C. Stadler;M. Chelbi-alix;M. Koken;L. Venturini;C. Lee;A. Saïb;F. Quignon;L. Pelicano;M. Guillemin;C. Schindler
通讯作者：
Mitchell C. Stadler;M. Chelbi-alix;M. Koken;L. Venturini;C. Lee;A. Saïb;F. Quignon;L. Pelicano;M. Guillemin;C. Schindler
影响因子：
3.1
作者：
M. Schleiss;M. McVoy
通讯作者：
M. Schleiss;M. McVoy
DOI：
10.5501/wjv.v2.i3.110
发表时间：
2013-08
期刊：
World journal of virology
影响因子：
--
作者：
Yisel Rivera-Molina;F. Martínez;Qiyi Tang
通讯作者：
Yisel Rivera-Molina;F. Martínez;Qiyi Tang
影响因子：
3.8
作者：
MAUL, GG;GULDNER, HH;SPIVACK, JG
通讯作者：
SPIVACK, JG
DOI：
10.1073/pnas.93.21.11321
发表时间：
1996-10-15
影响因子：
11.1
作者：
Mocarski, ES;Kemble, GW;Greaves, RF
通讯作者：
Greaves, RF