Dynamics of fatty acid vesicles in response to pH stimuli
Dynamics of fatty acid vesicles in response to pH stimuli
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DOI：
10.1039/c5sm01248a
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发表时间：
2015-01-01
期刊：
影响因子：
3.4
通讯作者：
Rasmussen, Steen
中科院分区：
文献类型：
--
作者：
Ikari, Keita;Sakuma, Yuka;Rasmussen, Steen
我们研究了对pH刺激的响应的动态的酸/癸酸(DA)囊泡。相继观察到了NaOH溶液微量注入引起的两种动力学过程：形变和拓扑转变。在变形阶段，DA囊泡表现出一系列的形状变形，即长圆形-扁圆形-气孔细胞球状。在拓扑转换阶段，球形DA囊泡遵循两种途径中的一种，即孔道形成和囊泡融合。PH刺激改变了DA分子的临界聚集浓度，从而导致DA分子在囊泡双层外层小叶中的增溶。这种增溶作用减小了囊泡的外表面积，从而增加了表面张力。基于面积差弹性理论的动力学模型可以准确地描述pH刺激引发的DA囊泡的动力学。
We investigate the dynamics of decanoic acid/decanoate (DA) vesicles in response to pH stimuli. Two types of dynamic processes induced by the micro-injection of NaOH solutions are sequentially observed: deformations and topological transitions. In the deformation stage, DA vesicles show a series of shape deformations, i.e., prolate-oblate-stomatocyte-sphere. In the topological transition stage, spherical DA vesicles follow either of the two pathways, pore formation and vesicle fusion. The pH stimuli modify a critical aggregation concentration of DA molecules, which causes the solubilization of DA molecules in the outer leaflet of the vesicle bilayers. This solubilization decreases the outer surface area of the vesicle, thereby increasing surface tension. A kinetic model based on area difference elasticity theory can accurately describe the dynamics of DA vesicles triggered by pH stimuli.