Possible differences in modes of agonist and antagonist binding at human 5-HT6 receptors.
Possible differences in modes of agonist and antagonist binding at human 5-HT6 receptors.
复制标题
人类 5-HT6 受体激动剂和拮抗剂结合模式可能存在差异。
DOI：
10.1016/j.bmcl.2004.05.076
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Glennon,RichardA
中科院分区：
文献类型：
--
作者：
Pullagurla,ManikR;Westkaemper,RichardB;Glennon,RichardA
构建了人类5- ht6受体的图形模型，并进行了自动对接研究。该模型提示5- ht6拮抗剂芳基磺酰基色胺可能与激动剂5-羟色胺结合不同。此外，该模型解释了我们之前的结构亲和性研究的许多实证结果。
A graphics model of the human 5-HT6receptor was constructed and automated docking studies were performed. The model suggests that 5-HT6antagonist arylsulfonyltryptamines might bind differently than that of the agonist serotonin. Furthermore, the model explains many of the empirical results from our previous structure–affinity studies.