Molecular X-ray computed tomography of myelin in a rat brain
Molecular X-ray computed tomography of myelin in a rat brain
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DOI：
10.1016/j.neuroimage.2011.04.013
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发表时间：
2011-07-01
期刊：
影响因子：
5.7
通讯作者：
Pfeiffer, F.
中科院分区：
文献类型：
--
作者：
Jensen, T. H.;Bech, M.;Pfeiffer, F.
在这项工作中，我们证明了应用小角度X射线散射计算机断层扫描（SAXS-CT）的非侵入性分子成像的髓鞘在大鼠大脑的可行性。我们的研究结果表明，该方法产生的信息上的几个数量，包括相对髓鞘浓度，其周期性，髓鞘的总厚度，和相对浓度的细胞骨架神经丝。例如，髓鞘的周期性在17.0至18.2 nm的范围内变化，平均值为17.6（+/-0.3）nm。我们认为，成像，即，空间分辨地测量这些量可以提供用于理解与许多神经变性疾病的关系的一般手段。(C)2011 Elsevier Inc. All rights reserved.
In this work we demonstrate the feasibility of applying small-angle X-ray scattering computed tomography (SAXS-CT) for non-invasive molecular imaging of myelin sheaths in a rat brain. Our results show that the approach yields information on several quantities, including the relative myelin concentration, its periodicity, the total thickness of the myelin sheaths, and the relative concentration of cytoskeletal neurofilaments. For example the periodicity of the myelin sheaths varied in the range from 17.0 to 18.2 nm around an average of 17.6 (+/- 0.3)nm. We believe that imaging, i.e., spatially resolved measuring these quantities could provide general means for understanding the relation to a number of neurodegenerative diseases. (C) 2011 Elsevier Inc. All rights reserved.