Can High-Sensitivity C-Reactive Protein and Ferritin Predict Functional Outcome in Acute Ischemic Stroke? A Prospective Study
Can High-Sensitivity C-Reactive Protein and Ferritin Predict Functional Outcome in Acute Ischemic Stroke? A Prospective Study
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DOI：
10.1310/tsr2006-528
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发表时间：
2013-11
影响因子：
2.2
通讯作者：
Aslihan Kusvuran Ozkan;O. Umit Yemisci;Sacide Nur Saraçgil Coşar;Pinar Oztop;N. Turhan
中科院分区：
文献类型：
--
作者：
Aslihan Kusvuran Ozkan;O. Umit Yemisci;Sacide Nur Saraçgil Coşar;Pinar Oztop;N. Turhan
摘要背景：炎症不仅可能是脑梗塞的结果，而且还可能导致缺血性损伤。然而，炎症标志物在预测中风功能结果中的作用仍然存在争议。目的：本研究旨在评估入院高敏C反应蛋白（hs-CRP）和铁蛋白水平对急性缺血性脑卒中患者3个月随访时功能障碍的预测价值，并探讨炎症标志物与缺血性脑卒中亚型、严重程度和危险因素之间的关系。方法：对 62 名患者在缺血性卒中发病后 48 小时内进行前瞻性检查。在发病后 48 小时内和 3 个月随访时对患者进行血浆 hs-CRP 和铁蛋白测量。根据 hs-CRP 水平将患者分为 2 组：升高组（血清 hs-CRP ≥0.5 mg/dL）和正常组（血清 hs-CRP 0.05）。结论：这项研究表明，hs-CRP 和铁蛋白水平都不能预测中风发病后 3 个月的功能障碍。 FIM、FAS 和 NIHSS 评分在预测中风发作后 3 个月后的功能结果方面比本研究中评估的实验室标记物更有用。
Abstract Background: Inflammation may not only be the consequence of brain infarction but it may also contribute to ischemic damage. However, the role of inflammatory markers in predicting functional outcome in stroke remains controversial. Objective: This study was conducted to evaluate the predictive value of admission high-sensitivity C-reactive protein (hs-CRP) and ferritin levels for functional disability in patients with acute ischemic stroke at 3-month follow-up and investigate the relationship between inflammatory markers and subtypes, severity, and risk factors of ischemic stroke. Methods: Sixty-two patients were examined prospectively within 48 hours after onset of ischemic stroke. Plasma hs-CRP and ferritin measurements were obtained from patients within 48 hours after onset and at 3-month follow-up. Patients were divided into 2 groups based on the level of hs-CRP: elevated (serum hs-CRP ≥0.5 mg/dL) and normal (serum hs-CRP .05). Conclusion: This study revealed that neither hs-CRP nor ferritin levels could predict functional disability 3 months after stroke onset. FIM, FAS, and NIHSS scores were more useful in predicting functional outcome 3 months after stroke onset than the laboratory markers evaluated in this study.