Graphene-Based Scaffolds: Fundamentals and Applications for Cardiovascular Tissue Engineering.
Graphene-Based Scaffolds: Fundamentals and Applications for Cardiovascular Tissue Engineering.
复制标题
DOI：
10.3389/fbioe.2021.797340
复制
发表时间：
2021
影响因子：
5.7
通讯作者：
Molokanova E
中科院分区：
文献类型：
--
作者：
Savchenko A;Yin RT;Kireev D;Efimov IR;Molokanova E
心脏组织工程需要能够忠实再现和支持天然体内微环境的材料，同时提供无缝的生物电子接口。目前细胞支架的局限性包括缺乏导电性和机械性能欠佳。在这里，我们讨论将石墨烯单独或与其他材料结合到细胞支架中如何影响心肌细胞的形态、功能和成熟。我们得出的结论是，基于石墨烯的支架在心脏组织工程方面具有广阔的前景。
Cardiac tissue engineering requires materials that can faithfully recapitulate and support the native in vivo microenvironment while providing a seamless bioelectronic interface. Current limitations of cell scaffolds include the lack of electrical conductivity and suboptimal mechanical properties. Here we discuss how the incorporation of graphene into cellular scaffolds, either alone or in combination with other materials, can affect morphology, function, and maturation of cardiac cells. We conclude that graphene-based scaffolds hold great promise for cardiac tissue engineering.