Analyses of the evolutionary distribution of Salmonella translocated effectors
Analyses of the evolutionary distribution of Salmonella translocated effectors
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DOI：
10.1128/iai.70.3.1619-1622.2002
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发表时间：
2002-03-01
影响因子：
3.1
通讯作者：
Hensel, M
中科院分区：
文献类型：
--
作者：
Hansen-Wester, I;Stecher, B;Hensel, M
沙门氏菌致病性岛2 （SPI2）编码的III型分泌系统将沙门氏菌易位效应物（STE）转运到宿主细胞中。STE由SPI2外的基因编码。调查了STE基因座在沙门氏菌中的分布。与SPI2基因座在肠沙门氏菌中保守相反，STE基因座的分布是可变的。除了其他毒力决定因素外，不同STE位点的拥有可能导致肠链球菌血清型的不同宿主范围和致病潜力。
The type III secretion system encoded by Salmonella pathogenicity island 2 (SPI2) translocates Salmonella translocated effectors (STE) into host cells. STE are encoded by genes outside of SPI2. The distribution of STE loci within the salmonellae was investigated. In contrast to the SPI2 locus that is conserved within Salmonella enterica, STE loci show a variable distribution. In addition to other virulence determinants, the possession of various sets of STE loci may contribute to the different host ranges and pathogenic potentials of S. enterica serovars.