Successful combination chemotherapy for metastatic parathyroid carcinoma.
Successful combination chemotherapy for metastatic parathyroid carcinoma.
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成功治疗转移性甲状旁腺癌的联合化疗。
DOI：
10.1001/archinte.1984.00350140229032
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发表时间：
1984
影响因子：
--
通讯作者：
C. Esselstyn
中科院分区：
文献类型：
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作者：
R. Bukowski;L. Sheeler;J. Cunningham;C. Esselstyn
一名 54 岁的转移性甲状旁腺癌患者，常规治疗难治性严重高钙血症，接受化疗，包括氟尿嘧啶，每日 500 mg/m2 静脉注射 (IV)，持续四天（24 小时输注），环磷酰胺，每日 500 mg/m2，静脉注射，持续四天，达卡巴嗪（咪唑甲酰胺），每日 200 mg/m2，静脉注射，持续四天。记录了完整的客观反应和部分生化反应，反应持续时间为 5.0 + 个月。毒性反应为中度，主要是胃肠道毒性反应。
A 54-year-old patient with metastatic parathyroid carcinoma and severe hypercalcemia refractory to conventional treatment was treated with chemotherapy consisting of fluorouracil, 500 mg/sq m intravenously (IV) daily for four days (24-hour infusion), cyclophosphamide, 500 mg/sq m IV daily for four days, and dacarbazine (imidazole carboxamide), 200 mg/sq m IV daily for four days. Complete objective and partial biochemical responses were noted, with the response duration being 5.0 + months. The toxic reaction was moderate and predominantly gastrointestinal.