Innovative Recruitment Strategies to Increase Diversity of Participation in Parkinsons Disease Research: The Fox Insight Cohort Experience
Innovative Recruitment Strategies to Increase Diversity of Participation in Parkinsons Disease Research: The Fox Insight Cohort Experience
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DOI：
10.3233/jpd-191901
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发表时间：
2020-01-01
影响因子：
5.2
通讯作者：
Tanner, Carolin M.
中科院分区：
文献类型：
--
作者：
Dobkin, Roseanne D.;Amondikar, Ninad;Tanner, Carolin M.
背景：帕金森病（PD）的临床研究由于参与者招募不足和缺乏多样性两个相互关联的问题而面临现实和伦理挑战。Fox Insight （FI）是一项基于网络的纵向研究，收集全球患者报告的结果和基因数据，为治疗研究提供信息。FI的在线平台提供了一个机会来评估招募大型、多样化研究队列的在线策略。目的：该项目旨在确定1)与传统的招募方法相比，FI的数字营销是否与总体和代表性不足的患者群体的入学率增加有关；2)在线招募样本的临床和人口学特征，以及3)在线招募的成本。方法：将6周基线期无数字推广的FI招募与几个数字推广期的招募进行比较。单独的在线招聘间隔包括一般的在线学习推广和针对代表性不足的子群体的独特的Facebook和谷歌广告活动：早期PD，晚期/晚期PD，以及代表性不足/农村地理区域的居民。结果：与基线相比，早期帕金森病、晚期帕金森病和地理定位运动在各自的队列中招募了更多的个体。所有在线活动也产生了更多的FI总登记人数，吸引了更多的非白人、西班牙裔、老年人、女性、教育程度和收入较低、医疗合并症较多的参与者。每位新参与者的成本从21美元（Facebook）到108美元（谷歌）不等。结论：数字营销可以使研究人员增加、加速和多样化PD临床研究的招聘，通过定制针对PD队列特征的数字广告。
Background: Clinical research in Parkinson's disease (PD) faces practical and ethical challenges due to two interrelated problems: participant under-recruitment and lack of diversity. Fox Insight (FI) is a web-based longitudinal study collecting patient-reported outcomes and genetic data worldwide to inform therapeutic studies. FI's online platform provides an opportunity to evaluate online strategies for recruiting large, diverse research cohorts. Objective: This project aimed to determine 1) whether FI's digital marketingwas associated with increased enrollment overall and from under-represented patient groups, compared to traditional recruitment methods; 2) the clinical and demographic characteristics of samples recruited online, and 3) the cost of this online recruitment. Method: FI recruitment during a 6-week baseline period without digital promotion was compared to recruitment during several periods of digital outreach. Separate online recruiting intervals included general online study promotion and unique Facebook and Google ad campaigns targeting under-represented subgroups: early PD, late/advanced PD, and residents of underrepresented/rural geographic areas. Results: Early PD, late PD, and geotargeting campaigns enrolled more individuals in their respective cohorts compared to baseline. All online campaigns also yielded greater total FI enrollment, attracting more participants who were non-White, Hispanic, older, female, and had lower educational attainment and income, and more medical comorbidities. Cost per new participant ranged from $21 (Facebook) to $108 (Google). Conclusion: Digital marketing may allowresearchers to increase, accelerate, and diversify recruitment for PD clinical studies, by tailoring digital ads to target PD cohort characteristics.