Reproducibility and simplification of 13C-octanoic acid breath test for gastric emptying of solids
Reproducibility and simplification of 13C-octanoic acid breath test for gastric emptying of solids
复制标题
DOI：
10.1111/j.1572-0241.1998.092_c.x
复制
发表时间：
1998-01-01
影响因子：
9.8
通讯作者：
Nair, KS
中科院分区：
文献类型：
--
作者：
Choi, MG;Camilleri, M;Nair, KS
目的：C-13-辛酸呼气试验的准确性通过在6小时而不是4小时内进行呼气采样而提高，但这增加了试验的成本。我们的目的是验证一种成本较低但准确的呼吸采样序列，用于测量固体胃排空。研究方法：我们进行的C-13-辛酸呼气试验，并测试其相对于同步呼气图在30名健康志愿者的再现性。打高跷：在通过两个测试测量的t（1/2）之间存在显著但弱的相关性（r（s）= 0.54，p <0.005），但在滞后期的持续时间之间不存在相关性。试验之间t（1/2）测量值的差异在受试者之间不同，但在受试者内具有高度重现性。C-13-辛酸呼气试验胃排空测量值的受试者内和受试者间变化与造影观察到的变化无显著差异。在6小时内收集的11个呼吸样本的子集（24个样本）预测（r（2）> 0.95）表征呼吸中（CO2）-C-13累积出现的变量;这些样品在35、30、95、110、140、155、215、245、260、290和335分钟时，该采样时间子集的准确性在来自相同30名受试者的6小时呼吸测试样本的单独集合中得到证实，结论：用于固体胃排空的C-13-辛酸呼气试验的重现性与胃排空造影术相同。11个采样时间的子集提供了足够的信息来表征整个呼吸测试曲线，但采样时间应延长至给药后6小时。(C)1998年，我胃肠病学。
Objective: The accuracy of the C-13-octanoic acid breath test is enhanced bk breath sampling over 6 h rather than 4 h, but this increases the cost of the test. Our ain was to validate a less costly but accurate sequence of breath sampling for measuring gastric emptying of solids. Methods: We performance the C-13-octanoic acid breath test and tested its reproducibility relative to simultaneous scintigraphy in 30 healthy volunteers. Hit stilts: There was a significant but weak correlation between t(1/2) measured by the two tests (r(s) = 0.54, p < 0.005), but not between the duration of the lag phase. The differences in the t(1/2) measurements between the tests were different between subjects but were highly reproducible within subjects, Within- and between-subject variations of measurements of gastric emptying with the C-13-octanoic acid breath test were not significantly different from the variations observed with scintigraphy. A subset of 11 breath samples collected over 6 h (24 samples) predicted (r(2) > 0.95) the variables characterizing the cumulative appearance of (CO2)-C-13 in breath; these samples were at 35, 30, 95, 110, 140, 155, 215, 245, 260, 290, and 335 min, The accuracy of this subset of sampling times was confirmed in a separate set of breath test samples over 6 h from the same 30 subjects, Conclusions: The C-13-octanoic acid breath test for gastric emptying of solids is as reproducible as scintigraphy. A subset of 11 sampling times provides sufficient information to characterize the whole breath-test curve, but the sampling period should be extended to 6 h after dosing. (C) 1998 by Am. Coll. of Gastroenterology.