A Turkish Gynecologic Oncology Group study of fertility-sparing treatment for early-stage endometrial cancer
A Turkish Gynecologic Oncology Group study of fertility-sparing treatment for early-stage endometrial cancer
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DOI：
10.1016/j.ijgo.2012.06.010
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发表时间：
2012-12-01
影响因子：
3.8
通讯作者：
Ayhan, Ali
中科院分区：
文献类型：
--
作者：
Dursun, Polat;Erkanli, Serkan;Ayhan, Ali
目的：分析土耳其妇科肿瘤中心早期子宫内膜癌（EC）患者保留生育能力治疗的结果，并对文献进行回顾。方法：联系了土耳其的13个医疗保健中心，以确定他们是否有资格参加本研究。符合条件并同意参与的中心被发送一份数据库表格，记录其EC患者的人口统计学特征、临床病理发现和随访结果。结果：11个土耳其医疗保健中心提供了43例EC患者的数据。平均治疗时间5个月，平均随访时间49个月。总共有35例（81.4%）患者在初次孕激素治疗后肿瘤消失。从黄体酮治疗结束到怀孕的平均时间为10.6±4.3个月（范围3-18个月）。随访期间2例肿瘤复发。在31名积极寻求怀孕的妇女中，怀孕率为41.9% （n = 13）。结论：口服孕激素对育龄妇女早期EC的保守治疗是有效的，且不影响肿瘤预后。研究患者的妊娠是自然和人工实现的。(C) 2012年国际妇产科联合会。爱思唯尔爱尔兰有限公司出版。版权所有。
Objective: To analyze the results of fertility-sparing treatment of early-stage endometrial cancer (EC) in patients treated at Turkish gynecologic oncology centers, and to present a review of the literature. Methods: Thirteen healthcare centers in Turkey were contacted to determine if they were eligible to participate in the study. Centers that were eligible and agreed to participate were sent a database form to record the demographic characteristics, clinicopathologic findings, and follow-up results for their EC patients. Results: Eleven Turkish healthcare centers provided data on 43 EC patients. Mean duration of treatment was 5 months and mean follow-up was 49 months. In total, 35 (81.4%) patients were tumor free following primary progesterone therapy. Mean time from the end of progesterone therapy to pregnancy was 10.6 +/- 4.3 months (range, 3-18 months). Two patients had tumor recurrence during follow-up. The pregnancy rate among the 31 women who actively sought pregnancy was 41.9% (n = 13). Conclusion: Conservative management of early-stage EC in women of reproductive age using oral progestins was effective and did not compromise oncological outcome. Pregnancy in the study patients was achieved spontaneously and artificially. (C) 2012 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.