IgM Antibodies Specific for Epstein-Barr Virus in Infectious Mononucleosis without Heterophil Antibodies
IgM Antibodies Specific for Epstein-Barr Virus in Infectious Mononucleosis without Heterophil Antibodies
复制标题
无异嗜细胞抗体的传染性单核细胞增多症中 Epstein-Barr 病毒特异性 IgM 抗体
DOI：
10.1136/bmj.4.5936.72
复制
发表时间：
1974
影响因子：
--
通讯作者：
E. Klemola
中科院分区：
文献类型：
--
作者：
J. Nikoskelainen;J. Leikola;E. Klemola
爱泼斯坦-巴尔（E.B.）在46名诊断为传染性单核细胞增多症而无嗜异性抗体的患者中，除1名患者外，所有患者均证实存在巨细胞病毒感染;巨细胞病毒病因被排除在外。在所有情况下，除了两种情况外，第一份样品中的滴度最高。在21例患者中，在几周内观察到显著下降。IgG抗体病毒，大多保持在一个恒定的水平，是在所有情况下证明。抗EB病毒IgM抗体在300个对照组中只有5个发现了病毒。结果表明，在一种类似传染性单核细胞增多症的疾病中，如果没有嗜异性抗体，则暂时性E. B。病毒特异性IgM抗体使快速病原学诊断成为可能，并且在临床明确的病例中，病毒和巨细胞病毒不太可能是致病因子。
IgM antibodies specific for Epstein-Barr (E.B.) virus were demonstrable in all but one out of 46 patients diagnosed as having infectious mononucleosis wihout heterophil antibodies; cytomegalovirus aetiology was excluded. In all but two cases the highest titre was found in the first sample. In 21 patients a significant decrease was seen within a few weeks. IgG antibodies to E.B. virus, mostly remaining at a constant level, were demonstrable in all cases. IgM antibodies to E.B. virus were found in only five out of 300 controls. The results suggest that in a disease similar to infectious mononucleosis without heterophil antibodies testing of transient E.B. virus-specific IgM antibodies makes a rapid aetiological diagnosis possible and that in clinically well-defined cases viruses other than E.B. virus and cytomegalovirus are unlikely to be causal agents.