Sleep patterns over 21-day period in rats with chronic constriction of sciatic nerve
Sleep patterns over 21-day period in rats with chronic constriction of sciatic nerve
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DOI：
10.1016/s0006-8993(03)03095-6
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发表时间：
2003-09-12
期刊：
影响因子：
2.9
通讯作者：
Tufik, S
中科院分区：
文献类型：
--
作者：
Andersen, ML;Tufik, S
本研究的主要目的是检查坐骨神经收缩引起的周围神经病变模型中大鼠 21 天的睡眠模式。对记录的评估表明，慢性缩窄性损伤（CCI）会引起睡眠改变，例如睡眠效率降低和觉醒次数增加，尤其是在光照期间。在这些改变中，睡眠模式在第 2 天到第 10 天之间受到的影响最大。在光照期间，CCI 后的第 2 天到第 7 天，大鼠需要更长的时间才能入睡。此外，在 CCI 后的第二天到第四天，在光明期和黑暗期记录中，第一次矛盾睡眠发作的潜伏期都减少了。总之，坐骨神经收缩导致大鼠睡眠质量差，睡眠中断，特别是在这种情况的第一周。 (C) 2003 Elsevier B.V. 保留所有权利。
The main purpose of the present study was to examine sleep patterns over 21-day periods of rats in a peripheral neuropathy model induced by sciatic nerve constriction. Evaluation of the recordings showed that chronic constrictive injury (CCI) induced sleep alterations such as reduced sleep efficiency and increased number of arousals, especially during the light period. Among these alterations, sleep patterns were most affected between day 2 and day 10. The rats took longer to get to sleep from day 2 to 7 days after the CCI in the light period. Additionally, latency to the first paradoxical sleep episode was reduced in the second to fourth day after CCI in both light and dark period recordings. In conclusion, sciatic nerve constriction induced poor sleep quality with disrupted sleep in rats, particularly during the first week of that condition. (C) 2003 Elsevier B.V. All rights reserved.