Ascorbic acid protects the newborn rat brain from hypoxic-ischemia
Ascorbic acid protects the newborn rat brain from hypoxic-ischemia
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DOI：
10.1016/j.braindev.2008.06.010
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发表时间：
2009-04-01
影响因子：
1.7
通讯作者：
Takahashi, Tsutomu
中科院分区：
文献类型：
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作者：
Miura, Shinobu;Ishida-Nakajima, Wako;Takahashi, Tsutomu
抗坏血酸（AA）是一种有效的抗氧化剂，其神经保护作用尚未确定。使用 Rice Vannucci 模型，我们检查了 AA 油缺氧缺血 (HI) 损伤对未成熟大鼠大脑的影响。异氟烷麻醉下，7日龄大鼠PUPS在缺氧前腹腔注射750 mg/kg AA； 8%，氧气90分钟。车辆对照接受等量的盐水。与媒介物对照相比，HI 后 48 和 168 11 AA 降低了宏观脑损伤评分（HI 后 48 小时，AA 1.38 + 10.45 与对照 2.94 + 0.24，p
Ascorbic acid (AA) is a potent antioxidant, and its neuro protective effect has not been established yet. Using the Rice Vannucci model, we examined the effect of AA oil hypoxic ischemic (HI) injury in the immature rat brain. Under isoflurane anesthesia, 7-day-old rat PUPS received 750 mg/kg of AA by intraperitoneal injection just before hypoxic exposure; 8%, oxygen for 90 min. Vehicle controls received an equal volume of saline. AA decreased a macroscopic brain injury score at 48 and 168 11 post-H I compared with vehicle controls (48 h post-HI, AA 1.38 + 10.45 vs. controls 2.94 + 0.24, p