The SO(H)L(H) "O" drivers of oocyte growth and survival but not meiosis I.
The SO(H)L(H) "O" drivers of oocyte growth and survival but not meiosis I.
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SO(H)L(H)“O”驱动卵母细胞生长和存活，但不是减数分裂 I。
DOI：
10.1172/jci94665
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Kumar,TRajendra
中科院分区：
文献类型：
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作者：
Kumar,TRajendra
精子发生/卵子发生螺旋-环-螺旋（SOHLH）蛋白SOHLH 1和SOHLH 2在雄性和雌性生殖中起重要作用。虽然以前的研究表明，这些转录调控表达，并在出生后的卵巢在体内的作用，其在胚胎卵巢的表达和功能仍然在很大程度上未知。由于卵母细胞分化与减数分裂的开始紧密相连，因此确定早期卵母细胞转录因子如何调节这两个过程具有重要意义。在本期的JCI中，Shin及其同事报道了SOHLH 1和SOHLH 2在胚胎卵巢中表现出不同的表达模式，并与其他卵母细胞特异性转录因子相互作用以调节卵母细胞分化。有趣的是，即使出生后卵巢中的卵母细胞快速丢失，同时Sohlh 1和Sohlh 2也丢失，减数分裂不受影响并正常进行。
The spermatogenesis/oogenesis helix-loop-helix (SOHLH) proteins SOHLH1 and SOHLH2 play important roles in male and female reproduction. Although previous studies indicate that these transcriptional regulators are expressed in and have in vivo roles in postnatal ovaries, their expression and function in the embryonic ovary remain largely unknown. Because oocyte differentiation is tightly coupled with the onset of meiosis, it is of significant interest to determine how early oocyte transcription factors regulate these two processes. In this issue of theJCI, Shin and colleagues report that SOHLH1 and SOHLH2 demonstrate distinct expression patterns in the embryonic ovary and interact with each other and other oocyte-specific transcription factors to regulate oocyte differentiation. Interestingly, even though there is a rapid loss of oocytes postnatally in ovaries with combined loss ofSohlh1andSohlh2, meiosis is not affected and proceeds normally.