Gamma/alpha-zein hydrolysates as oral delivery vehicles: Enhanced physicochemical stability and invitro bioaccessibility of curcumin
Gamma/alpha-zein hydrolysates as oral delivery vehicles: Enhanced physicochemical stability and invitro bioaccessibility of curcumin
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γ/α-玉米醇溶蛋白水解物作为口服给药载体：增强姜黄素的理化稳定性和体外生物可及性
DOI：
10.1111/ijfs.13744
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发表时间：
2018-07-01
影响因子：
3.3
通讯作者：
Yang, Xiaoquan
中科院分区：
文献类型：
--
作者：
Pan, Runting;Zou, Yuan;Yang, Xiaoquan
在这项研究中，我们的目的是评估潜在的玉米醇溶蛋白水解物（ZH）作为一种新的疏水生物活性分子，如姜黄素（Cur）的传递系统。通过氢键和疏水作用，成功地形成了粒径为50-60 nm的-ZH-Cur配合物（-ZH-Cur）。与-ZH相比，-ZH中Cur的络合物显示出更好地改善了Cur的水溶性和理化稳定性，并显示出Cur的持续释放和更大的吸收潜力。Cur在-ZH和-ZH之间的装载能力、物理化学储存和生物可及性的差异可能与氨基酸组成和肽的典型序列的差异有关。这些结果表明，与-ZH相比，-ZH具有更好的能力作为疏水生物活性分子的新型递送。
In this study, we aimed to evaluate the potential of the -zein hydrolysate (-ZH) as a new delivery system for hydrophobic bioactive molecules such as curcumin (Cur). -ZH-Cur complexes (-ZH-Cur) with a particle size of 50-60 nm were successfully formed via the hydrogen bonding and hydrophobic interactions. Compared to -ZH, the complexation of Cur in -ZH showed a better improvement in the water solubility and physicochemical stability of Cur and showed sustained release and greater potential for absorption of Cur. The differences in the loading capability, the physicochemical storage and the bioaccessibility of Cur between -ZH and -ZH may be associated with the differences in the amino acid composition and typical sequence of peptides. These results indicate that -ZH has a better ability to serve as a novel delivery for the hydrophobic bioactive molecules compared to -ZH.