Genornics and the evolution, pathogenesis, and diagnosis of tuberculosis
Genornics and the evolution, pathogenesis, and diagnosis of tuberculosis
复制标题
DOI：
10.1172/jci31810
复制
发表时间：
2007-07-01
影响因子：
15.9
通讯作者：
Banaiee, Niaz
中科院分区：
文献类型：
--
作者：
Ernst, Joel D.;Trevejo-Nunez, Giraldina;Banaiee, Niaz
结核病每年导致近 200 万人死亡，目前的结核病控制方法价格昂贵、功效有限，并且容易被广泛耐药的结核分枝杆菌菌株所克服。结核分枝杆菌基因组序列的确定彻底改变了结核病研究，促进了对结核分枝杆菌进化和发病机制的理解的重大进展，并促进了新的诊断测试的开发，提高了结核病的特异性。在这篇综述中，我们描述了结核病研究中因基因组序列知识而取得的一些重大进展，并指出了一些尚未解决的问题。
Tuberculosis kills nearly 2 million people annually, and current approaches to tuberculosis con trol are expensive, have limited efficacy, and are vulnerable to being overcome by extensively drug-resistant strains of Mycobacterium tuberculosis. Determination of the genome sequence of M. tuberculosis has revolutionized tuberculosis research, contributed to major advances in the understanding of the evolution and pathogenesis of M. tuberculosis, and facilitated development of new diagnostic tests with increased specificity for tuberculosis. In this review, we describe some of the major progress in tuberculosis research that has resulted from knowledge of the genome sequence and note some of the problems that remain unsolved.