REGULATION OF METABOLISM OF 25-HYDROXYCHOLECALCIFEROL BY KIDNEY TISSUE IN-VITRO BY DIETARY CALCIUM
REGULATION OF METABOLISM OF 25-HYDROXYCHOLECALCIFEROL BY KIDNEY TISSUE IN-VITRO BY DIETARY CALCIUM
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DOI：
10.1038/newbio237063a0
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发表时间：
1972-01-01
期刊：
影响因子：
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通讯作者：
DELUCA, HF
中科院分区：
文献类型：
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作者：
OMDAHL, JL;BOYLE, IT;DELUCA, HF
现在认识到，维生素D的羟基化代谢物（即胆钙化醇）作为最初归因于未改变的维生素1的生理作用的效应物发挥作用。维生素D通过特定的羟基化反应的活化和所产生的代谢物通过靶组织的螯合代表了反馈敏感的激素控制回路。25-羟基胆钙化醇（25-HCC）和1，25-二羟基胆钙化醇（1，25-DHCC）已被证明是控制回路的参与者，维生素D首先在肝脏中代谢为25-HCC 2，25-HCC 2又在肾脏中在C-1位羟基化为1，25-DHCC 3，4。在肠道中的代谢活性形式似乎是1，25-DHCC 5，6。
IT is now recognized that hydroxylated metabolites of vitamin D (that is, cholecalciferol) function as effectors of the physiological actions originally attributed to the unaltered vitamin1. The activation of vitamin D by specific hydroxylation reactions and sequestration of the resultant metabolites by target tissues represents a hormonal control loop which is feed-back sensitive. 25-Hydroxycholecalciferol (25-HCC) and 1,25-dihydroxycholecalciferol (1,25-DHCC) have been shown to be participants in the control loop, vitamin D being first metabolized in the liver to 25-HCC2which in turn is hydroxylated in the C-1 position to 1,25-DHCC in the kidney3,4. The metabolically active form in the intestine appears to be 1,25-DHCC5,6.