Effect of intrauterine undernutrition during late gestation on pancreatic β cell mass
Effect of intrauterine undernutrition during late gestation on pancreatic β cell mass
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DOI：
10.2220/biomedres.30.325
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发表时间：
2009-12-01
影响因子：
1.2
通讯作者：
Kasuga, Masato
中科院分区：
文献类型：
--
作者：
Inoue, Tae;Kido, Yoshiaki;Kasuga, Masato
我们分析了低出生体重对胰腺β细胞质量的影响。我们使用怀孕的C57 BL 6 J小鼠，在妊娠晚期将其食物供应减少30%，并检查代谢和胰腺β细胞质量的变化。与对照组（CG）小鼠相比，限食组（RG）小鼠出生时的胰腺β细胞质量大大降低。RG小鼠的体重表现出“追赶生长”模式，出生后7天与CG小鼠相当，此后超过CG小鼠;然而，RG小鼠的胰腺β细胞质量在4周龄时仍低于CG小鼠。与12周龄的CG小鼠相比，高脂肪饮食显著增加了RG小鼠的胰腺β细胞质量。然而，饲喂高脂饲料的RG小鼠在约20周龄时倾向于表现出胰腺β细胞质量的减少。与CG小鼠相比，24周龄后RG小鼠的血浆胰岛素浓度也有降低的趋势。因此，这些结果表明，在RG小鼠中胰腺β细胞的生长不足，并且胰腺β细胞衰竭可以容易地发展为胰岛素抵抗的结果。
We analyzed the effect of low birth weight oil pancreatic beta cell mass. We used pregnant C57BL6J mice, and we reduced their food Supply by 30% during the late gestational period and examined the changes in the metabolism and pancreatic beta cell mass. Pancreatic beta cell mass at birth was greatly decreased in the mice of the food restriction group (RG) as compared to the mice of the control group (CG). The body weight of RG mice exhibited a "catch-up growth" pattern and became equivalent to that of CG mice 7 days after birth, and thereafter exceeded that of CG mice; however, the pancreatic beta cell mass in RG mice remained lower than that in CG mice at the age of 4 weeks. A high-fat diet significantly increased the pancreatic beta cell mass in RG mice as compared to that in CG mice at 12 weeks of age. However, RG mice fed oil high-fat diets tended to exhibit a decrease in the pancreatic beta cell mass at approximately 20 weeks of age. The plasma insulin concentrations also tended to be decreased in RG mice after 24 weeks of age as compared to those of CG mice. These results thus indicate that the growth of pancreatic beta cells is insufficient in RG mice, and pancreatic beta cell Failure can easily develop as a consequence Of insulin resistance.