Catalyst‐Free Domino Reaction of 1‐Acryloyl‐1‐N‐arylcarbamylcyclopropanes with Amines: One‐Pot Approach to 2,3,6,7‐Tetrahydro‐1H‐pyrrolo[3,2‐c]pyridin‐4(5H)‐ones
Catalyst‐Free Domino Reaction of 1‐Acryloyl‐1‐N‐arylcarbamylcyclopropanes with Amines: One‐Pot Approach to 2,3,6,7‐Tetrahydro‐1H‐pyrrolo[3,2‐c]pyridin‐4(5H)‐ones
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DOI：
10.1002/adsc.201500251
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发表时间：
2015-08
影响因子：
5.4
通讯作者：
Zhiguo Zhang;Feisong Zhang;Huanhuan Wang;Hao Wu;Xinyu Duan;Qingfeng Liu;Tongxin Liu;Guisheng Zhang
中科院分区：
文献类型：
--
作者：
Zhiguo Zhang;Feisong Zhang;Huanhuan Wang;Hao Wu;Xinyu Duan;Qingfeng Liu;Tongxin Liu;Guisheng Zhang
以1-丙烯酰基-1-N-芳基氨基甲酰基环丙烷和胺为原料，采用多米诺开环/环合/氮杂加成反应，一锅法合成了2，3，6，7-四氢-1H-吡咯并[3，2-c]吡啶-4（5 H）-酮。
A facile one-pot, catalyst-free reaction has been developed for the synthesis of 2,3,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones from readily available 1-acryloyl-1-N-arylcarbamylcyclopropanes and amines using a domino ring-opening/cyclization/aza-addition sequence.