Acute kidney injury in the fetus and neonate
Acute kidney injury in the fetus and neonate
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DOI：
10.1016/j.siny.2016.12.001
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发表时间：
2017-04-01
影响因子：
3
通讯作者：
Askenazi, David J.
中科院分区：
文献类型：
--
作者：
Nada, Arwa;Bonachea, Elizabeth M.;Askenazi, David J.
急性肾损伤（阿基）是一种未被充分认识的新生儿发病率;由于该人群中阿基缺乏统一的定义，并且由于既往研究在血清肌酐和尿量评估筛查阿基方面差异很大，因此发病率仍不清楚。早产儿出生时的肾单位可能少于足月新生儿的一半，使他们在生命早期和随着年龄的增长易患慢性肾病（CKD）。阿基也可能导致CKD，患有阿基的早产儿可能面临长期肾脏问题的高风险。新生儿的阿基通常是多因素的，并且可能由产前、围产期或产后损伤以及其任何组合引起。本文就阿基的病因、早期发现的重要性、新生儿阿基的治疗及阿基的长期后遗症等方面进行综述。(C)2016爱思唯尔有限公司版权所有。
Acute kidney injury (AKI) is an under-recognized morbidity of neonates; the incidence remains unclear due to the absence of a unified definition of AKI in this population and because previous studies have varied greatly in screening for AKI with serum creatinine and urine output assessments. Premature infants may be born with less than half of the nephrons compared with term neonates, predisposing them to chronic kidney disease (CKD) early on in life and as they age. AKI can also lead to CKD, and premature infants with AKI may be at very high risk for long-term kidney problems. AKI in neonates is often multifactorial and may result from prenatal, perinatal, or postnatal insults as well as any combination thereof. This review focuses on the causes of AKI, the importance of early detection, the management of AKI in neonates, and long-term sequela of AKI in neonates. (C) 2016 Elsevier Ltd. All rights reserved.