Polymorphism of the beta(3)-adrenergic receptor gene affects basal metabolic rate in obese Finns
Polymorphism of the beta(3)-adrenergic receptor gene affects basal metabolic rate in obese Finns
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DOI：
10.2337/diabetes.46.1.77
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发表时间：
1997-01-01
期刊：
影响因子：
7.7
通讯作者：
Laakso, M
中科院分区：
文献类型：
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作者：
Sipilainen, R;Uusitupa, M;Laakso, M
低基础代谢率（BMR）是体重增加和肥胖的危险因素，β（3）-肾上腺素能受体基因第64位密码子多态性与BMR相关。我们研究了β（3）-肾上腺素能受体基因Trp 64 Arg的频率以及该多态性对肥胖芬兰人BMR的影响，共有170名肥胖受试者（29名男性，141名女性，BMI 34.7 +/- 3.8 kg/m（2），平均值+/- SD）参与了研究，Trp 64 Arg多态性的频率为19%，没有一个肥胖受试者是Arg编码等位基因的纯合子，肥胖芬兰人中Trp 64 Arg多态性的频率与非肥胖和血糖正常的对照受试者没有差异，Trp 64 Arg多态性受试者（n = 20）的经瘦体重和年龄校正的BMR低于正常纯合子Trp 64 Trp（n = 99）（1，569 +/- 73 vs，1，635 +/- 142 kcal/天，P = 0.004），对于女性组（n = 98），相应值分别为1，501 +/- 66 kcal/天vs，1，568 +/- 127 kcal/天（P = 0.004），Trp 64 Arg基因多态性与非Trp 64 Arg基因多态性组在体重、BMI、腰臀比、瘦体重、脂肪百分比和呼吸商方面无显著性差异，两组之间的血糖和胰岛素水平均无差异。我们得出结论，β（3）-肾上腺素能受体基因的Trp 64 Arg多态性影响肥胖芬兰人的基础代谢率，但对葡萄糖代谢无显著影响。
Low basal metabolic rate (BMR) is a risk factor for weight gain and obesity, The polymorphism at codon 64 of the beta(3)-adrenergic receptor gene has been suggested to be associated with BMR. We investigated the frequency of the Trp64Arg of the beta(3)-adrenergic receptor gene and the effects of this polymorphism on BMR in obese Finns, Altogether, 170 obese subjects (29 men, 141 women, BMI 34.7 +/- 3.8 kg/m(2), mean +/- SD) participated in the study, The frequency of the Trp64Arg polymorphism was 19%, None of the obese subjects were homozygous for the Arg-encoding allele, The frequency of the Trp64Arg polymorphism in obese Finns did not differ from nonobese and normoglycemic control subjects, BMR adjusted for lean body mass and age was lower in subjects with the Trp64Arg polymorphism (n = 20) than in normal homozygotes Trp64Trp (n = 99) (1,569 +/- 73 vs, 1,635 +/- 142 kcal/day, P = 0.004), For the female group (n = 98), the respective values were 1,501 +/- 66 kcal/day vs, 1,568 +/- 127 kcal/day (P = 0.004), There were no significant differences in weight, BMI, waist-to-hip ratio, lean body mass, percentage of fat, and respiratory quotient between the groups with or without the Trp64Arg polymorphism, Neither serum glucose nor insulin levels differed between the two groups, We conclude that the Trp64Arg polymorphism of the beta(3)-adrenergic receptor gene affects basal metabolic rate in obese Finns but does not have significant effect on glucose metabolism.